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Overview

Uniprot IDD3ZUV9
Protein NameCCR4-NOT transcription complex subunit 3
Gene NameCnot3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
105 TKTKAYSKEGLGLAQ
72 WVASNEIKDKRQLIE

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity

Protein Sequence

10 MADKRKLQGE 20 IDRCLKKVSE 30 GVEQFEDIWQ 40 KLHNAANANQ 50 KEKYEADLKK 60 EIKKLQRLRD 70 QIKTWVASNE 80 IKDKRQLIEN 90 RKLIETQMER 100 FKVVERETKT 110 KAYSKEGLGL 120 AQKVDPAQKE 130 KEEVGQWLTN 140 TIDTLNMQVD 150 QFESEVESLS 160 VQTRKKKGDK 170 DKQDRIEGLK 180 RHIEKHRYHV 190 RMLETILRML 200 DNDSILVDAI 210 RKIKDDVEYY 220 VDSSQDPDFE 230 ENEFLYDDLD 240 LEDIPQALVA 250 TSPPSHSHME 260 DEIFNQSSST 270 PTSTTSSSPI 280 PPSPANCTTE 290 NSEDDKKRGR 300 STDSEVSQSP 310 AKNGSKPVHS 320 NQHPQSPAVP 330 PTYPSGPPPA 340 TSALSSTPGN 350 NGASTPAAPP 360 SALGPKASPA 370 PSHNSGTPAP 380 YAQAVAPPNA 390 SGPSNAQPRP 400 PSAQPSGGSG 410 GGSGGSSSNS 420 NSGTGGGAGK 430 QNGATSYSSV 440 VADSPAEVAL 450 SSSGGSSASS 460 QALGPTSGPH 470 NPAPSTLKES 480 STAAPSGAGS 490 VASGSGNNSG 500 GPSLLVPLPV 510 NPPSSPTPSF 520 SEAKAAGTLL 530 NGPPQFSTTP 540 EIKAPEPLSS 550 LKSMAERAAI 560 SSGIEDPVPT 570 LHLTDRDIIL 580 SSTSAPPTSS 590 QPPLQLSEVN 600 IPLSLGVCPL 610 GPVSLTKEQL 620 YQQAMEEAAW 630 HHMPHPSDSE 640 RIRQYLPRNP 650 CPTPPYHHQM 660 PPPHSDTVEF 670 YQRLSTETLF 680 FIFYYLEGTK 690 AQYLAAKALK 700 KQSWRFHTKY 710 MMWFQRHEEP 720 KTITDEFEQI 730 SAPLFVHSLT 740 TFFPGQGTYI 750 YFDYEKWGQR 760 KKEGFTFEYR YLEDRDLQ

Gene Ontology

Classification GO ID Description
Biological Process GO:0031047 regulatory ncRNA-mediated gene silencing
Cellular Component GO:0030014 CCR4-NOT complex
Cellular Component GO:0030015 CCR4-NOT core complex
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0010467 gene expression
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:2000036 regulation of stem cell population maintenance
Biological Process GO:0006417 regulation of translation
Biological Process GO:0001829 trophectodermal cell differentiation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.