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Overview

Uniprot ID	D3ZV54
Protein Name	Periodic tryptophan protein 2 homolog
Gene Name	Pwp2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
233	LKAPRGWKADILQRE
262	RETTIRGKAVPAEQE

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MKFAYRFSNL 20 LGTVYRCGNL 30 NFSRDGNSVI 40 SPVGNRVTVF 50 DLKNNRSDTL 60 PLATKYNIKC 70 VGLSPDGRLA 80 IIVDEGGAAL 90 LVSLVCRSVL 100 HHFHFKGSVH 110 SVSFSPDGRK 120 FVITKGNIAQ 130 MYHAPGKKRE 140 FNAFVLDKTY 150 FGPYDETTCI 160 DWTDDSKCFV 170 VGSKDMSTWV 180 FGAERWDNLI 190 YYALSGHKDA 200 IVACFFESNS 210 LDLYSLSQDG 220 ALCVWQCDTP 230 PEGLRLKAPR 240 GWKADILQRE 250 KEEEEEEDEE 260 GEGNRETTIR 270 GKAVPAEQER 280 VGKVKYSRLA 290 KYFLNKEGDF 300 NNLTAAAYHK 310 KTHLLVTGFA 320 SGIFHLHELP 330 EFNLIHSLSI 340 SDQRVASVAI 350 NSSGDWIAFG 360 CSGLGQLLVW 370 EWQSESYVLK 380 QQGHFNSMVA 390 LAYSPDGQYI 400 VTGGDDGKVK 410 VWNTLSGFCF 420 VTLTEHSSGV 430 TGVTFTATGH 440 VIVTSSLDGT 450 VRAYDLHRYR 460 NFRTFTSPRP 470 TQFSCVAVDS 480 SGEIVSAGAQ 490 DSFEIFVWSM 500 QTGRLLDVLS 510 GHEGPISGLC 520 FNPMKSILAS 530 ASWDKTVRLW 540 DMFDSWRTKE 550 TLSLTSDVLA 560 VTYRPDGAEL 570 AVATLNSQIT 580 FWDPENAVQV 590 GSIEGRHDLK 600 TGRKELDKIT 610 AKHSAKGKAF 620 TTVCYSADGQ 630 NILAGGMSKF 640 VCLYHVREQI 650 LVKRFELSCN 660 FSLDAMEEFL 670 NRRKMTEFGN 680 LALIDQDAGE 690 ENGVAIPLPG 700 VRKGDMSSRH 710 FKPEIRVTSL 720 RFSPTGRCWA 730 ATSTEGLLIF 740 SLDAQMLFDP 750 FELDTSVTPG 760 RIREALRQRE 770 FTRAILMAFR 780 LNEKKLAQEA 790 LEAVPQNEIE 800 VVSASLPELY 810 VVKVLEFLAA 820 SFEESRHLEF 830 YLIWTQKLLM 840 SHGQRLKSRA 850 GQLLPVVQFL 860 QKGLQRHLDD 870 ISKLCDWNRY 880 NIQYALAVSK 890 QRGMKRTLEP 900 VDTEEDTDAS 910 DEDSLHLLRA 920 AEEEEEGMLV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
Cellular Component	GO:0032040	small-subunit processome
Biological Process	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0000028	ribosomal small subunit assembly
Biological Process	GO:0042274	ribosomal small subunit biogenesis

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.