Search Results
Overview
| Uniprot ID | D3ZVD8 |
|---|---|
| Protein Name | Protein deacetylase HDAC6 |
| Gene Name | Hdac6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 901 | SASPVSAKGMTTPKG |
| 909 | GMTTPKGKVLEAGMR |
| 917 | VLEAGMRKPTAALPT |
| 933 | ESTLGQAKAKTAKAL |
| 938 | QAKAKTAKALLAQGQ |
Function
No function data available.
Protein Sequence
10
MRARGHTGRR
20
EFGGASQGRS
30
LERGQCSSRS
40
RSKGSSAMTS
50
TGQDSSTRQR
60
KSRHNPQSPL
70
QDSSATLKRG
80
GKKGAVPHSS
90
PNLAEVKKKG
100
KMKKLSQPAE
110
EDLIVGLQGL
120
DLNSETRVPV
130
GTGLVFDEQL
140
NDFHCLWDDS
150
FPENPERLHA
160
IKEQLILEGL
170
LGRCVSFQAR
180
FAEKEELMLV
190
HSLEYIDLME
200
TTQYMNEGEL
210
RVLAGTYDSV
220
YLHPNSYSCA
230
CLATGSVLRL
240
VDAVMGAEIR
250
NGMAVIRPPG
260
HHAQRSLMDG
270
YCMFNHLAVA
280
ARYAQKKHRI
290
QRILIVDWDV
300
HHGQGTQFIF
310
DQDPSVLYFS
320
IHRYEHGRFW
330
PHLKASNWST
340
TGFGQGQGYT
350
INVPWNQVGM
360
RDADYIAAFL
370
HILLPVAFEF
380
QPQLVLVAAG
390
FDALHGDPKG
400
EMSATPAGFA
410
HLTHFLMGLA
420
GGKLILSLEG
430
GYNLHALAKG
440
VSGSLHTLLG
450
DPCPMLESPV
460
APCASAQTSI
470
SCTLEALEPF
480
WEVLERSVEP
490
QDEDEVEGDM
500
LEDEEEEGHW
510
EATALPMDTW
520
PLLQNRTGLV
530
YDERMMSHCN
540
LWDNHHPETP
550
QRILRIMCHL
560
EEVGLAARCL
570
ILPARPALDS
580
ELLTCHSAEY
590
VERLRATEKM
600
KTRDLHREGA
610
NFESIYICPS
620
TFACAQLATG
630
AACRLVEAVL
640
SGEVLNGIAI
650
VRPPGHHAEP
660
DAACGFCFFN
670
SVAVAARHAQ
680
VIAGRALRIL
690
IVDWDVHHGN
700
GTQHIFEEDP
710
SVLYVSLHRY
720
DRGTFFPMGD
730
EGASSQVGRA
740
AGTGFTVNVP
750
WNGPRMGDAD
760
YLATWHRLVL
770
PIAYEFNPEL
780
VLISAGFDAA
790
QGDPLGGCQV
800
TPEGYAHLTH
810
LLMGLAGGRI
820
ILILEGGYNL
830
TSISESMAAC
840
THSLLGDPPP
850
QLTSLRPPQS
860
GALASISEVI
870
QVHRKYWRSL
880
RLMKMEDKEE
890
RSSSRLVIKK
900
LPQSASPVSA
910
KGMTTPKGKV
920
LEAGMRKPTA
930
ALPTKESTLG
940
QAKAKTAKAL
950
LAQGQSSEQA
960
AKGTTLDLAT
970
SKDTVGGATT
980
DQCASVAATE
990
NSANQTTSGE
1000
EASGETESFG
1010
TSPSSNASKQ
1020
TTGASPLHGA
1030
AAQQSPELGL
1040
SSTLELSSEA
1050
QEVQESEEGL
1060
LGEAAGGQDM
1070
NSLMLTQGFG
1080
DFNTQDVFYA
1090
VTPLSWCPHL
1100
MAVCPIPAAG
1110
LDVSQPCKTC
1120
GSVQENWVCL
1130
TCYQVYCSRY
1140
VNAHMVCHHE
1150
ASEHPLVLSC
1160
VDLSTWCYLC
1170
QAYVHHEDLQ
1180
DVKNAAHQNK
FGEGMPHLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016235 | aggresome |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000153 | cytoplasmic ubiquitin ligase complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0042030 | ATPase inhibitor activity |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0019213 | deacetylase activity |
| Molecular Function | GO:0070840 | dynein complex binding |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0036479 | peroxidase inhibitor activity |
| Molecular Function | GO:0031593 | polyubiquitin modification-dependent protein binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Molecular Function | GO:0042903 | tubulin deacetylase activity |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0070842 | aggresome assembly |
| Biological Process | GO:0019896 | axonal transport of mitochondrion |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0035967 | cellular response to topologically incorrect protein |
| Biological Process | GO:0061523 | cilium disassembly |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:1905336 | negative regulation of aggrephagy |
| Biological Process | GO:0045814 | negative regulation of gene expression, epigenetic |
| Biological Process | GO:0010727 | negative regulation of hydrogen peroxide metabolic process |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:0043242 | negative regulation of protein-containing complex disassembly |
| Biological Process | GO:0045861 | negative regulation of proteolysis |
| Biological Process | GO:0070845 | polyubiquitinated misfolded protein transport |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0032461 | positive regulation of protein oligomerization |
| Biological Process | GO:1905091 | positive regulation of type 2 mitophagy |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:0006515 | protein quality control for misfolded or incompletely synthesized proteins |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0060632 | regulation of microtubule-based movement |
| Biological Process | GO:0051788 | response to misfolded protein |
| Biological Process | GO:0090042 | tubulin deacetylation |
| Biological Process | GO:0061734 | type 2 mitophagy |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.