Search Results

Overview

Uniprot IDD3ZVQ0
Protein NameUbiquitin carboxyl-terminal hydrolase
Gene NameUsp5
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
291 LKMQKTDKTMTELEI

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes

Protein Sequence

10 MAELSEEALL 20 SVLPTIRVPK 30 AGDRVHKDEC 40 AFSFDTPESE 50 GGLYICMNTF 60 LGFGKQYVER 70 HFNKTGQRVY 80 LHLRRTRRPK 90 EEDSSAGTGD 100 PPRKKPTRLA 110 IGVEGGFDLT 120 EDKFEYDEDV 130 KIVILPDYLE 140 IARDGLGGLP 150 DIVRDRVTSA 160 VEALLSADSA 170 SRKQEVQAWD 180 GEVRQVSKHA 190 FNLKQLDNPA 200 RIPPCGWRCS 210 KCDMRENLWL 220 NLTDGSILCG 230 RRYFDGSGGN 240 NHAVEHYRET 250 GYPLAVKLGT 260 ITPDGADVYS 270 YDEDDMVLDP 280 SLAEHLSHFG 290 IDMLKMQKTD 300 KTMTELEIDM 310 NQRIGEWELI 320 QESGVPLKPL 330 FGPGYTGIRN 340 LGNSCYLNSV 350 VQVLFSIPDF 360 QRKYVDKLEK 370 IFQNAPTDPT 380 QDFSTQVAKL 390 GHGLLSGEYS 400 KPALESGDGE 410 QVPEQKEVQD 420 GIAPRMFKAL 430 IGKGHPEFST 440 NRQQDAQEFF 450 LHLINMVERN 460 CRSSENPNEV 470 FRFLVEEKIK 480 CLATEKVKYT 490 QRVDYIMQLP 500 VPMDAALNKE 510 ELLEYEEKKR 520 QAEEEKVALP 530 ELVRAQVPFS 540 SCLEAYGAPE 550 QVDDFWSTAL 560 QAKSVAVKTT 570 RFASFPDYLV 580 IQIKKFTFGL 590 DWVPKKLDVS 600 IEMPEELDIS 610 QLRGTGLQPG 620 EEELPDIAPP 630 LVTPDEPKGS 640 LGFYGNEDED 650 SFCSPHFSSP 660 TSPMLDESVV 670 IQLVEMGFPM 680 DACRKAVYYT 690 GNSGAEAAMN 700 WVMSHMDDPD 710 FANPLILPGS 720 SGPGSTSAAA 730 DPPPEDCVAT 740 IVSMGFSRDQ 750 ALKALRATNN 760 SLERAVDWIF 770 SHIDDLDAEA 780 AMDISEGRSA 790 ADSISESVPV 800 GPKVRDGPGK 810 YQLFAFISHM 820 GTSTMCGHYV 830 CHIKKEGRWV 840 IYNDQKVCAS 850 EKPPKDLGYI YFYQRVVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098793 presynapse
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0101005 deubiquitinase activity
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0002841 negative regulation of T cell mediated immune response to tumor cell
Biological Process GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0140251 regulation protein catabolic process at presynapse

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.