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Overview

Uniprot IDD3ZVT2
Protein NametRNA (32-2'-O)-methyltransferase regulator THADA
Gene NameThada
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1193 ALSADDSKGRVPQVH

Function

Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs

Protein Sequence

10 MGVKKKREMQ 20 FAALTVCHQD 30 LETLRSFADV 40 EGKNLASLLL 50 HCVQLTDGVS 60 QIHSVKQIVP 70 LLEKVDKNGV 80 CDPIIQRCLD 90 ILASIYFSLT 100 LKNPLKKVLA 110 SSLNGLPECF 120 LNEAAHSFTF 130 HLQEELDTAD 140 LHSYRKVMDN 150 ISSCMENFNL 160 GRASVVNLLQ 170 NVLHFLQKSL 180 IEVQEENRKF 190 AGNHIVQTQL 200 MNDLLVGVRV 210 AMTLVQKVQG 220 PQSNLWNDSS 230 SPIWQSMCGL 240 LSIFTRFLND 250 DDLLQTIQST 260 SGLAVILFIK 270 TMFRPSEKLP 280 GLISSLLLQS 290 ADCTSIPDWL 300 MSSCRSLCCA 310 DVPASALLFL 320 CQGTLAMLDW 330 QDGSMGPSRE 340 ALLLDTVHVL 350 FTLSSQIKES 360 TLEMFLSRIL 370 ASWTNSAIQI 380 LESSSPSLKD 390 HLNGDSSIPR 400 RLLEYVYTHW 410 EHPLDALRHQ 420 TKIIFRNLLQ 430 MHRLTIEGAD 440 LVTDPFFLEL 450 TKSLLQLEWH 460 IKGKYACLGY 470 LVESLGIEHI 480 LAIDKTIPSQ 490 ILEVMGDQSL 500 VPYASDLLET 510 MFKNHKSHLK 520 SQTVTNTWMD 530 KWHETWVFPV 540 LSVLCGGNLD 550 QRSYVIDYYL 560 PRLLNYSPES 570 LHYMVQILQT 580 PIDTETGSCN 590 HRGALGALMA 600 CLRTARAHGH 610 LQSATHAWEN 620 LVCSARVKQG 630 LIHQHCQVRI 640 DTLGLLCESS 650 RSTEVVSREE 660 MQWVQFFLTY 670 NLNSQSPGVR 680 QQICSLLTKL 690 FCRIQESSQV 700 LYKLEQRNST 710 PDSEKRSTRE 720 QPSVSLQQYK 730 NFMSSVCNIL 740 FEALFPGSSY 750 STRFSALTIL 760 GSIAEVFPAS 770 KGNIQTVYQL 780 SHDIDAGRFQ 790 ILMECFTSTF 800 EEVKTLAFDL 810 LMNLSSVTAG 820 QLQGSEKLQD 830 LFQAALELST 840 STKPYDCVTA 850 SYLLNLLIWQ 860 DALPASLSAS 870 SAQQPTCGAG 880 EKSAVVERNT 890 LVVIKCLMEN 900 LEDEISQAEN 910 SLLQAASSFP 920 MYGRVHCITR 930 AFQKLPLHDL 940 RLVSEWKPVL 950 GKLLLLSYRL 960 STVVSPVIQS 970 SSPEGLIPMD 980 TDSESASRLQ 990 VILNEIQPRD 1000 TNDYFSQAKI 1010 LKECDSFDLE 1020 DLSTSVSNID 1030 SSAEIKGKEE 1040 KACDVTAQMV 1050 LTCCWRSMKE 1060 VALLLGTLCQ 1070 LLPLQPVPES 1080 AAGLLTVQQV 1090 KEIGEYFKQH 1100 LLQSRHRGAF 1110 ELAYTGFVKL 1120 TEILNRCSNV 1130 SLQKLPEQWL 1140 WSVLEEIKSS 1150 DPSSKLCATR 1160 RSAGIPFYIQ 1170 ALLASEPKKG 1180 RMDLLRVTMR 1190 ELISLALSAD 1200 DSKGRVPQVH 1210 ALNILRALFR 1220 DTRLGENIIP 1230 YVAGGAKAAI 1240 LGFTSPVWAV 1250 RNSSTLLFSS 1260 LITRVFGVKR 1270 GKDELSKTNR 1280 MTGREFFSRF 1290 PELYPFLLKQ 1300 LETVANTVDS 1310 DLGDPDGHPG 1320 MFLLLLVLER 1330 LYPSPMDGTA 1340 STLSLAPFVP 1350 FIIRCGRSPF 1360 YRSREMAARA 1370 LVPFITIDQI 1380 PSTLHALLDS 1390 LPSSTDQCFR 1400 QNHIHGTLLQ 1410 VFHLLQAYIT 1420 DSKHRINADF 1430 LQELSDITVC 1440 TKAKLWLAMR 1450 QNPCLVTRAV 1460 YIDILFLLTH 1470 CLDRPEEGKH 1480 TALESLDFWE 1490 DVRRIILGSE 1500 LITGFPWTFK 1510 VPGLPQYLQS 1520 LTKLAIPEVW 1530 ASLAEAEGQA 1540 TAVPLSFSQL 1550 LKSSFPEVRL 1560 LALDALLERA 1570 ASSEQGQKGP 1580 PPLLYSMGEE 1590 FLLLAMKEDH 1600 PGCFCRVLKI 1610 LYHLNPSEWL 1620 PQTECSVHLS 1630 PKEFLVWTMD 1640 IASNDRSEIQ 1650 GVSLRLASKI 1660 IAYLVQSCEK 1670 NKDSVALELR 1680 RWVQLIVWSC 1690 GDHLPTASRL 1700 AVAEVLSGTA 1710 PLFLTSPQPI 1720 LDLQDTLSLW 1730 RCVLTLLQSE 1740 EQPVREAATE 1750 TVTTAMSQGN 1760 TCQSTEFAFC 1770 QVDASIALTL 1780 AFAVLCDLLQ 1790 QWDQLGPGLP 1800 ILLGWLLEEG 1810 GDLKDLMQSP 1820 HQGEEEHIFE 1830 KSEVNFWAET 1840 LTFVKYLCNQ 1850 VFHLLCQSGC 1860 QSSHSQLSHL 1870 QRTASEQHRL 1880 ISQLFRELPL 1890 SAEFLKTVEY 1900 TRLRIQEERT 1910 LAVLRLLACL 1920 EGKEVLRAED 1930 CPREWRQEMA PRTEAAC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Molecular Function GO:0030234 enzyme regulator activity
Biological Process GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
Biological Process GO:0002128 tRNA nucleoside ribose methylation

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.