Search Results
Overview
| Uniprot ID | D3ZVT2 |
|---|---|
| Protein Name | tRNA (32-2'-O)-methyltransferase regulator THADA |
| Gene Name | Thada |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1193 | ALSADDSKGRVPQVH |
Function
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs
Protein Sequence
10
MGVKKKREMQ
20
FAALTVCHQD
30
LETLRSFADV
40
EGKNLASLLL
50
HCVQLTDGVS
60
QIHSVKQIVP
70
LLEKVDKNGV
80
CDPIIQRCLD
90
ILASIYFSLT
100
LKNPLKKVLA
110
SSLNGLPECF
120
LNEAAHSFTF
130
HLQEELDTAD
140
LHSYRKVMDN
150
ISSCMENFNL
160
GRASVVNLLQ
170
NVLHFLQKSL
180
IEVQEENRKF
190
AGNHIVQTQL
200
MNDLLVGVRV
210
AMTLVQKVQG
220
PQSNLWNDSS
230
SPIWQSMCGL
240
LSIFTRFLND
250
DDLLQTIQST
260
SGLAVILFIK
270
TMFRPSEKLP
280
GLISSLLLQS
290
ADCTSIPDWL
300
MSSCRSLCCA
310
DVPASALLFL
320
CQGTLAMLDW
330
QDGSMGPSRE
340
ALLLDTVHVL
350
FTLSSQIKES
360
TLEMFLSRIL
370
ASWTNSAIQI
380
LESSSPSLKD
390
HLNGDSSIPR
400
RLLEYVYTHW
410
EHPLDALRHQ
420
TKIIFRNLLQ
430
MHRLTIEGAD
440
LVTDPFFLEL
450
TKSLLQLEWH
460
IKGKYACLGY
470
LVESLGIEHI
480
LAIDKTIPSQ
490
ILEVMGDQSL
500
VPYASDLLET
510
MFKNHKSHLK
520
SQTVTNTWMD
530
KWHETWVFPV
540
LSVLCGGNLD
550
QRSYVIDYYL
560
PRLLNYSPES
570
LHYMVQILQT
580
PIDTETGSCN
590
HRGALGALMA
600
CLRTARAHGH
610
LQSATHAWEN
620
LVCSARVKQG
630
LIHQHCQVRI
640
DTLGLLCESS
650
RSTEVVSREE
660
MQWVQFFLTY
670
NLNSQSPGVR
680
QQICSLLTKL
690
FCRIQESSQV
700
LYKLEQRNST
710
PDSEKRSTRE
720
QPSVSLQQYK
730
NFMSSVCNIL
740
FEALFPGSSY
750
STRFSALTIL
760
GSIAEVFPAS
770
KGNIQTVYQL
780
SHDIDAGRFQ
790
ILMECFTSTF
800
EEVKTLAFDL
810
LMNLSSVTAG
820
QLQGSEKLQD
830
LFQAALELST
840
STKPYDCVTA
850
SYLLNLLIWQ
860
DALPASLSAS
870
SAQQPTCGAG
880
EKSAVVERNT
890
LVVIKCLMEN
900
LEDEISQAEN
910
SLLQAASSFP
920
MYGRVHCITR
930
AFQKLPLHDL
940
RLVSEWKPVL
950
GKLLLLSYRL
960
STVVSPVIQS
970
SSPEGLIPMD
980
TDSESASRLQ
990
VILNEIQPRD
1000
TNDYFSQAKI
1010
LKECDSFDLE
1020
DLSTSVSNID
1030
SSAEIKGKEE
1040
KACDVTAQMV
1050
LTCCWRSMKE
1060
VALLLGTLCQ
1070
LLPLQPVPES
1080
AAGLLTVQQV
1090
KEIGEYFKQH
1100
LLQSRHRGAF
1110
ELAYTGFVKL
1120
TEILNRCSNV
1130
SLQKLPEQWL
1140
WSVLEEIKSS
1150
DPSSKLCATR
1160
RSAGIPFYIQ
1170
ALLASEPKKG
1180
RMDLLRVTMR
1190
ELISLALSAD
1200
DSKGRVPQVH
1210
ALNILRALFR
1220
DTRLGENIIP
1230
YVAGGAKAAI
1240
LGFTSPVWAV
1250
RNSSTLLFSS
1260
LITRVFGVKR
1270
GKDELSKTNR
1280
MTGREFFSRF
1290
PELYPFLLKQ
1300
LETVANTVDS
1310
DLGDPDGHPG
1320
MFLLLLVLER
1330
LYPSPMDGTA
1340
STLSLAPFVP
1350
FIIRCGRSPF
1360
YRSREMAARA
1370
LVPFITIDQI
1380
PSTLHALLDS
1390
LPSSTDQCFR
1400
QNHIHGTLLQ
1410
VFHLLQAYIT
1420
DSKHRINADF
1430
LQELSDITVC
1440
TKAKLWLAMR
1450
QNPCLVTRAV
1460
YIDILFLLTH
1470
CLDRPEEGKH
1480
TALESLDFWE
1490
DVRRIILGSE
1500
LITGFPWTFK
1510
VPGLPQYLQS
1520
LTKLAIPEVW
1530
ASLAEAEGQA
1540
TAVPLSFSQL
1550
LKSSFPEVRL
1560
LALDALLERA
1570
ASSEQGQKGP
1580
PPLLYSMGEE
1590
FLLLAMKEDH
1600
PGCFCRVLKI
1610
LYHLNPSEWL
1620
PQTECSVHLS
1630
PKEFLVWTMD
1640
IASNDRSEIQ
1650
GVSLRLASKI
1660
IAYLVQSCEK
1670
NKDSVALELR
1680
RWVQLIVWSC
1690
GDHLPTASRL
1700
AVAEVLSGTA
1710
PLFLTSPQPI
1720
LDLQDTLSLW
1730
RCVLTLLQSE
1740
EQPVREAATE
1750
TVTTAMSQGN
1760
TCQSTEFAFC
1770
QVDASIALTL
1780
AFAVLCDLLQ
1790
QWDQLGPGLP
1800
ILLGWLLEEG
1810
GDLKDLMQSP
1820
HQGEEEHIFE
1830
KSEVNFWAET
1840
LTFVKYLCNQ
1850
VFHLLCQSGC
1860
QSSHSQLSHL
1870
QRTASEQHRL
1880
ISQLFRELPL
1890
SAEFLKTVEY
1900
TRLRIQEERT
1910
LAVLRLLACL
1920
EGKEVLRAED
1930
CPREWRQEMA
PRTEAAC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Molecular Function | GO:0030234 | enzyme regulator activity |
| Biological Process | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration |
| Biological Process | GO:0002128 | tRNA nucleoside ribose methylation |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.