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Overview

Uniprot ID	D3ZVW3
Protein Name	Zinc finger CCCH domain-containing protein 4
Gene Name	Zc3h4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
135	LPKKSYSKIDSKGYS

Function

RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs

Protein Sequence

10 MLRGREDGEL 20 EEGELEDDGA 30 EDIQDTPGGQ 40 ERSRKEKGEK 50 HHSDSDEEKS 60 HRRLKRKRKK 70 EREKEKRRSK 80 KRRKSKHKRH 90 ASSSDDFSDF 100 SDDSDFSPSE 110 KGHRKYRDYS 120 PPYVPSHQQY 130 SSSHNTPLPK 140 KSYSKIDSKG 150 YSMYEDYENE 160 QYGEYEGDEE 170 EDMGKEDYDD 180 FTKELNQYRR 190 AKEGSSRGRG 200 SRGRGRGYRG 210 RGSRGGSRGR 220 GMGRGSRGRG 230 RGSMGEHPED 240 EEDLYDEEIE 250 YGESEEPMGD 260 DDYDEYSKEL 270 NQYRRSKDSR 280 GRGLSRGRGR 290 GSRGGRGKGM 300 GRGRGRGSRG 310 GMSKGGMNDE 320 DDFYDDDMGD 330 GGGGSYRRSD 340 HDKPHQQSDK 350 KGKVICKYFV 360 EGRCTWGDHC 370 NFSHDIELPK 380 KRELCKFYIT 390 GFCARAENCP 400 YIHERDFPCK 410 LYHTTGNCIN 420 GDDCMFSHDP 430 LTEETRELLD 440 KMLADDAEAG 450 AEDEKEVEEL 460 KKQGINPLPK 470 PPPGVGLLPT 480 PPRPPGPPAP 490 TSPNGRPMQG 500 GPPPPPPPPP 510 PPPGPPQMAM 520 PAHEPLSPQQ 530 LQQDMYNKKI 540 PSLFEIVVRP 550 TGQLAEKLGV 560 RFPGPGGPSG 570 PMGPGPNMGP 580 PGPMGGPMHP 590 DMHPDMHPDM 600 HPDMHPDMHP 610 DMHPDMHPDM 620 HPDMPMGPGM 630 NPGPPMGPGG 640 PPMMPYGPGD 650 SPHSGMMAPI 660 PPAQNFYENF 670 YPQQEGMEME 680 PGLVGDAEDY 690 GHYEELPGQP 700 GEPLFPEHPL 710 EPDSFPEGGP 720 PGRPKAGAGV 730 PDFLPSAQRA 740 LYLRIQQKQQ 750 EEERARRLAE 760 SSKQDRENEE 770 GDTGNWYSSD 780 EDEGGSSVTS 790 ILKTLRQQTS 800 SRPQASVGEP 810 SSSGLGDPRL 820 QKGHTTGGRL 830 ADPRLSRDPR 840 LSRHAETSGG 850 SGPGDSGPSD 860 PRLARALPTS 870 KTEGSLHSSP 880 ACPSGSKGQP 890 PAEEEEGERA 900 LREKAVTIPL 910 DPLPGHPLRD 920 PRSQLQQFSH 930 IKKDVTLSKP 940 SFARTVLWNP 950 EDLIPLPIPK 960 QDVPPVPAAL 970 QSLPALDPRL 980 HRSTPPGPPN 990 TRQQRPGSTD 1000 PSTSGSNLPD 1010 FELLSRILKT 1020 VNVNTPGQSE 1030 KPSDPRVRKT 1040 PTDPRLQKPA 1050 DPGAASRAAK 1060 PCPTEASPPA 1070 ASPSGDSPPA 1080 TAPYDPRVLA 1090 AGGLGQGSSS 1100 GQSSVLSGIS 1110 LYDPRTPNAG 1120 GKTAELTSDT 1130 SAQPKGPEGN 1140 GKSSASKAKE 1150 PPFVRKSALE 1160 QPETGKASTD 1170 GATATDRYNS 1180 YNRPRPKATA 1190 APTAASSTPP 1200 PEGATTQPGV 1210 HNLPVPTLFG 1220 TVKPTPKTGT 1230 GSPFAGNSPA 1240 REGEQDAGSL 1250 KDVFKGFDPT ASPFCQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0032785	negative regulation of DNA-templated transcription, elongation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.