Search Results
Overview
| Uniprot ID | D3ZW55 |
|---|---|
| Protein Name | Inosine triphosphate pyrophosphatase |
| Gene Name | Itpa |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | AEMPKAEKNTISHRF |
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions
Protein Sequence
10
MAASLVGKKI
20
VFVTGNAKKL
30
EEVIQILGDK
40
FPCTLVAQKI
50
DLPEYQGEPD
60
EISIQKCQEA
70
ARQVQGPVLV
80
EDTCLCFNAL
90
GGLPGPYIKW
100
FLQKLKPEGL
110
YQLLAGFEDK
120
SAYALCTFAL
130
STGDPSQPVL
140
LFRGKTPGQI
150
VMPRGSRDFG
160
WDPCFQPDGY
170
EQTYAEMPKA
180
EKNTISHRFR
190
ALFKLQEYFG
VTDGAGDH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0035870 | dITP diphosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036220 | ITP diphosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0047429 | nucleoside triphosphate diphosphatase activity |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0036222 | XTP diphosphatase activity |
| Biological Process | GO:0051276 | chromosome organization |
| Biological Process | GO:0009204 | deoxyribonucleoside triphosphate catabolic process |
| Biological Process | GO:0006193 | ITP catabolic process |
| Biological Process | GO:0009143 | nucleoside triphosphate catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.