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Overview

Uniprot ID	D3ZWC6
Protein Name	Beta-1-syntrophin
Gene Name	Sntb1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
315	DIREQLGKTGIAGSR

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex

Protein Sequence

10 MAVAAAAAAV 20 AAPAGGGGAR 30 AQRSGLLEVL 40 VRDRWHKVLV 50 NLSEDALVLS 60 CEEGATAYNG 70 IGTTTNGSFC 80 RGSGTGHPGT 90 GVPQAPDSPA 100 GVRTAFTDLP 110 EQVPESISNQ 120 KRGVKVLKQE 130 LGGLGISIKG 140 GKENKMPILI 150 SKIFKGLAAD 160 QTQALYVGDA 170 ILSVNGADLR 180 DATHDEAVQA 190 LKRAGKEVLL 200 EVKYMREATP 210 YVKKGSPVSE 220 IGWETPPPES 230 PRLGSGSADP 240 LSSQPFSFHR 250 DRKSIPLKMC 260 YVTRSMTLAD 270 PENRQLEIHS 280 PDAKHTVVLR 290 SKDSATAQAW 300 FSAIHSNVGD 310 LLVRVVADIR 320 EQLGKTGIAG 330 SREIRHLGWL 340 AEKVPGESEK 350 QWKPALVVLT 360 EKDLLIYDSM 370 PRRKEAWLSP 380 VHSYPLLATR 390 LVHSGPGKGS 400 PQAAMDLSFA 410 TRTGTKQGIE 420 THLFRAEISR 430 DLSHWTRSIV 440 QGCHNSAELT 450 AEITTACTYR 460 NQECRLTIHY 470 DNGFSISTEP 480 QDGAFPKTII 490 QSPYEKLKMS 500 SDDGIRMLYL 510 DFGGKEGEIQ 520 LDLHSCPKPI 530 VFIIHSFLSA KITRLGLVA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0016010	dystrophin-associated glycoprotein complex
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0042383	sarcolemma
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0030165	PDZ domain binding
Molecular Function	GO:0005198	structural molecule activity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.