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Overview

Uniprot IDD3ZWP6
Protein NamePlexin-A2
Gene NamePlxna2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1529 CDTITQVKEKILDAV

Function

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm

Protein Sequence

10 MEQRRFQLRA 20 MQADNLSVVL 30 LSVAWLLLAR 40 GTTGMPQFST 50 FHSENRDWTF 60 NHLTVHRRTG 70 AVYVGAINRV 80 YKLTGNLTIQ 90 VAHKTGPEED 100 NKACYPPLIV 110 QPCSEVLTLT 120 NNVNKLLIID 130 YSENRLLACG 140 SLYQGVCKLL 150 RLDDLFILVE 160 PSHKKEHYLS 170 SVNKTGTMYG 180 VIVRSEGEDG 190 KLFIGTAVDG 200 KQDYFPTLSS 210 RKLPRDPESS 220 AMLDYELHSD 230 FVSSLIKIPS 240 DTLALVSHFD 250 IFYIYGFASG 260 GFVYFLTVQP 270 ETPEGMAINS 280 AGDLFYTSRI 290 VRLCKDDPKF 300 HSYVSLPFGC 310 TRAGVEYRLL 320 QAAYLAKPGE 330 ALAQAFNISS 340 EEDVLFAIFS 350 KGQKQYHHPP 360 DDSALCAFPI 370 RAINLQIKER 380 LQSCYHGEGN 390 LELNWLLGKD 400 VQCTKAPVPI 410 DDNFCGLDIN 420 QPLGGSTPVE 430 GLTLYTTSRD 440 RLTSVASYVY 450 NGYSVVFVGT 460 KSGKLKKIRA 470 DGPPHGGVQY 480 EMVSVFKDGS 490 PILRDMAFSI 500 NQLYLYVMSE 510 RQVTRVPVES 520 CEQYTTCGEC 530 LSSGDPHCGW 540 CALHNMCSRR 550 DKCQRAWEAN 560 RFAASISQCM 570 SLEVHPNSIS 580 VSDHSRLLSL 590 VVNDAPNLSE 600 GIACAFGNLT 610 EVEGQVSGSQ 620 VICISPGPKD 630 VPVIPLDQDW 640 FGLELQLRSK 650 ETGKIFVSTE 660 FKFYNCSAHQ 670 LCLSCVNSAF 680 RCHWCKYRNL 690 CTHDPTTCSF 700 QEGRINVSED 710 CPQLVPTEEI 720 LIPVGEVKPI 730 TLKARNLPQP 740 QSGQRGYECV 750 LNIQGAVHRV 760 PALRFNSSSV 770 QCQNSSYQYD 780 GMDISNLAVD 790 FAVVWNGNFI 800 IDNPQDLKVH 810 LYKCAAQRES 820 CGLCLKADHK 830 FECGWCSGER 840 RCTLRQHCPS 850 TSSPWLDWSS 860 HNVKCSNPQI 870 TEILTVSGPP 880 EGGTRVTIHG 890 VNLGLDFSEI 900 AHHVQVAGVP 910 CTPIPGEYII 920 AEQIVCEMGH 930 ALMGTTSGPV 940 RLCIGECKPE 950 FMTKSHQQYT 960 FVNPSVLSLS 970 PIRGPESGGT 980 MVTITGHYLG 990 AGSSVAVYLG 1000 NQTCEFYGRS 1010 MNEIVCVSPP 1020 SSNGLGPVPV 1030 SVSVDRARVD 1040 SSLQFEYIDD 1050 PRVQRIEPEW 1060 SITSGHTPLT 1070 ITGFNLDVIQ 1080 EPRIRVKFNG 1090 KESVNVCTVV 1100 NTTTLTCLAP 1110 SLTSDYRPGL 1120 DTVERPDEFG 1130 FLFNNVQSLL 1140 IYNDTKFIYY 1150 PNPTFELLSP 1160 TGILDQKPGS 1170 PIILKGKNLC 1180 PPASGGAKLN 1190 YTVMIGETPC 1200 TVTVSETQLL 1210 CEPPNLTGQH 1220 KVMVHVGGMV 1230 FSPGSVSVIS 1240 DSLLTLPAII 1250 SIAAGGSLLL 1260 IIVIIVLIAY 1270 KRKSRENDLT 1280 LKRLQMQMDN 1290 LESRVALECK 1300 EAFAELQTDI 1310 NELTSDLDRS 1320 GIPYLDYRTY 1330 AMRVLFPGIE 1340 DHPVLRELEV 1350 QGNGQQHVEK 1360 ALKLFAQLIN 1370 NKVFLLTFIR 1380 TLELQRSFSM 1390 RDRGNVASLI 1400 MTGLQGRLEY 1410 ATDVLKQLLS 1420 DLIDKNLENK 1430 NHPKLLLRRT 1440 ESVAEKMLTN 1450 WFAFLLHKFL 1460 KECAGEPLFM 1470 LYCAIKQQME 1480 KGPIDAITGE 1490 ARYSLSEDKL 1500 IRQQIEYKTL 1510 ILNCVNPDNE 1520 NSPEIPVKVL 1530 NCDTITQVKE 1540 KILDAVYKNV 1550 PYSQRPRAVD 1560 MDLEWRQGRI 1570 ARVVLQDEDI 1580 TTKIEGDWKR 1590 LNTLMHYQVS 1600 DRSVVALVPK 1610 QTSSYNIPAS 1620 ASISRTSISR 1630 YDSSFRYTGS 1640 PDSLRSRVPM 1650 ITPDLESGVK 1660 VWHLVKNHDH 1670 GDQKEGDRGS 1680 KMVSEIYLTR 1690 LLATKGTLQK 1700 FVDDLFETLF 1710 STVHRGSALP 1720 LAIKYMFDFL 1730 DEQADRHSIH 1740 DTDVRHTWKS 1750 NCLPLRFWVN 1760 VIKNPQFVFD 1770 IHKGSITDAC 1780 LSVVAQTFMD 1790 SCSTSEHRLG 1800 KDSPSNKLLY 1810 AKDIPSYKNW 1820 VERYYADIAK 1830 LPAISDQDMN 1840 AYLAEQSRLH 1850 ATEFNMLSAL 1860 NEIYSYVSKY 1870 SEELIGALEQ 1880 DEQARRQRLA 1890 YKVEHLINAM SIES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002116 semaphorin receptor complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0017154 semaphorin receptor activity
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0051642 centrosome localization
Biological Process GO:0021935 cerebellar granule cell precursor tangential migration
Biological Process GO:0060174 limb bud formation
Biological Process GO:0021915 neural tube development
Biological Process GO:0060037 pharyngeal system development
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0120035 regulation of plasma membrane bounded cell projection organization
Biological Process GO:0071526 semaphorin-plexin signaling pathway
Biological Process GO:0001756 somitogenesis
Biological Process GO:0007416 synapse assembly

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.