Search Results
Overview
| Uniprot ID | D3ZXF9 |
|---|---|
| Protein Name | Large ribosomal subunit protein bL12m |
| Gene Name | Mrpl12 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | TEAKPVDKVKLIKEI |
| 228 | VKLIKEIKNYVQGIN |
| 240 | GINLVQAKKLVESLP |
| 241 | INLVQAKKLVESLPQ |
Function
As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability
Protein Sequence
10
MPRRAAGESS
20
DPVLFPGPDC
30
VCASRRLVRN
40
IRSQPSRPGR
50
QGLVARAARP
60
ARLLPDRASL
70
PLRAACDLPA
80
CGAMLPAAAA
90
AASRLWGPRL
100
GLGGSALRLV
110
RQQMPGVCVA
120
RQLRSSSHRR
130
SEALAGAPLD
140
NAPKEYPPKI
150
QQLVQDIASL
160
TLLEISDLNE
170
LLKKTLKIQD
180
VGLMPMGGMV
190
PGAVPAAAPA
200
PEAAEEEDLP
210
KQKEQTHFTV
220
RLTEAKPVDK
230
VKLIKEIKNY
240
VQGINLVQAK
250
KLVESLPQEI
260
KANVAKAEAE
270
KIKAALEAVG
GTVVLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0006390 | mitochondrial transcription |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006412 | translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.