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Overview

Uniprot ID	D3ZXK4
Protein Name	sn-1-specific diacylglycerol lipase ABHD11
Gene Name	Abhd11
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
192	IPHSRARKLADEQLS
203	EQLSSVVKISPQEAS

Function

Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol. 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols. Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts. In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs)

Protein Sequence

10 MFCWARAWRV 20 PRGTIGASSP 30 RSSAVPVTFS 40 SSRSSGQGNA 50 DPRPLPLSYN 60 LLDGDATLPA 70 IVLLHGLFGS 80 KSNFNSLAKA 90 LVQRTGRRVL 100 TVDARNHGDS 110 PHSPDASYEA 120 MSQDLQGLLP 130 QLGLVPSVLV 140 GHSMGGKTAM 150 LLALQRPDVV 160 ERLVVVDISP 170 AGTTPGSYLG 180 NFIAAMKAVD 190 IPENIPHSRA 200 RKLADEQLSS 210 VVKISPQEAS 220 VRQFLLTNLV 230 EVNGRFSWRV 240 NLDALAQQLD 250 KILTFPQQLE 260 SYPGSTLFLL 270 GGNSPYVPPS 280 HHSAIRRLFP 290 QTQIQTVPNA 300 GHWVHSDKPQ 310 DFMDAVISFL A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex
Molecular Function	GO:0016298	lipase activity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.