Search Results

Overview

Uniprot IDD3ZY40
Protein NamePre-mRNA cleavage complex 2 protein Pcf11
Gene NamePcf11
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
593 IENWQSSKSAKRWKS

Function

Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II

Protein Sequence

10 MSEQTPAEAG 20 AAGAREDACR 30 DYQSSLEDLT 40 FNSKPHINML 50 TILAEENLPF 60 AKEIVSLIEA 70 QTAKAPSSEK 80 LPVMYLMDSI 90 VKNVGREYLT 100 AFTKNLVATF 110 ICVFEKVDEN 120 TRKSLFKLRS 130 TWDEIFPLKK 140 LYALDVRVNS 150 LDPAWPIKPL 160 PPNVNTSSIH 170 VNPKFLNKSP 180 DEPSTPGTVV 190 SSPNISTPPI 200 VPDIQKNLTQ 210 EQLIRQQLLA 220 KQKQLLELQQ 230 KKLELELEQA 240 KAQLAVSLSV 250 QQETANLGPG 260 SAPSKLHVPQ 270 IPTMAVKTPH 280 QVPVQPDKSR 290 VGPSLQMQDL 300 KGTNRDPRLN 310 RMSQHSSHGK 320 EQSHRKEFVM 330 NTINQSDIKT 340 SKTVPSEKLN 350 SSKQEKSKSG 360 ERITKKELDQ 370 LDSKSKSKSK 380 SPSPLKNKLS 390 HTKDLKNQES 400 ESMRLSDMNK 410 RDPRLKKHLQ 420 DKAEGKDEDV 430 KEKRKTAEKK 440 DKDEHMKSSE 450 HRLIGSRSKI 460 INGVVQKQDM 470 VTEELEKQGT 480 KPGRSSTRKR 490 SRSRSPKSRS 500 PIVHSPKRRD 510 RRSPKRRQRS 520 MSPTLAPKAG 530 KMRQSGLKQS 540 HMDEFPPPSR 550 EERNIKRSAK 560 QDVRDPRRLK 570 KMDEDRPQET 580 AGQHSMKSGG 590 DPKENIENWQ 600 SSKSAKRWKS 610 GWEENKSLQQ 620 GDEHSKPPHL 630 RHRESWSSTK 640 GILSPRAPKQ 650 QHRLSVDANL 660 QIPKELTLAS 670 KRELLQKTSE 680 RLASGEITQD 690 EFLVVVHQIR 700 QLFQYQEGVR 710 EEQRSPFNDR 720 FPLKRPRYED 730 SDKPFVDGPA 740 SRFAGLDTNQ 750 RLTALAEDRP 760 LFDGPGRPSV 770 TRDGPTKMIF 780 EGPNKLSPRI 790 DGPPTPGSLR 800 FDGSPGQIGG 810 GGPMRFEGPQ 820 GQLGGGCPLR 830 FEGPPGPVGT 840 PLRFEGPIGQ 850 GGGGGFRFEG 860 SPSLRFEGSA 870 GGLRFEGPGG 880 QPVGGLRFEG 890 HRGQPVGGLR 900 FEGPHGQPVG 910 SLRFDNPRGQ 920 PVGGLRFEGG 930 HGPSGAAIRF 940 DGPHGQPGGG 950 IRFEGPLLQQ 960 GVGMRFEGPH 970 GQSVAGLRFE 980 GHNQLGGNLR 990 FEGPHGQPGV 1000 GIRFEGPLVQ 1010 QGGGMRFEGP 1020 VPGGGLRIEG 1030 PLGQGGPRFE 1040 GCHSLRFDGQ 1050 PGQPSLLPRF 1060 DGLHGQPGPR 1070 FERTGQPGPQ 1080 RFDGPPGQQV 1090 QPRFDGVPQR 1100 FDGPQHQQAS 1110 RFDIPLGLQG 1120 TRFDNHPSQR 1130 IESFNQTGPY 1140 SDPPGNAFNV 1150 PSQGLQFQRH 1160 EQIFDTPQGP 1170 NFNGPHGPGN 1180 QNFPNPINRP 1190 SGHYFDEKNL 1200 QSSQFGNFGN 1210 LPTPMSVGNI 1220 QTSQQVLTGV 1230 AQPVAFGQGQ 1240 QFLPVHPQNP 1250 GAFIQNPSGG 1260 LPKAYPDNHL 1270 SQVDVNELFS 1280 KLLKTGILKL 1290 SQPDSATAQV 1300 NEAVAQPPPE 1310 EEEDQNEDQD 1320 VPDLTNFTIE 1330 ELKQRYDSVI 1340 NRLYTGIQCY 1350 SCGMRFTTSQ 1360 TDVYADHLDW 1370 HYRQNRTEKD 1380 VSRKVTHRRW 1390 YYSLTDWIEF 1400 EEIADLEERA 1410 KSQFFEKVHE 1420 EVVLKTQEAA 1430 KEKEFQSVPA 1440 GPAGAVESCE 1450 ICQEQFEQYW 1460 DEEEEEWHLK 1470 NAIRVDGKVT 1480 FSSLYGITSS 1490 FDCTPSPSKT 1500 PVENPLNIML 1510 NIVKNELQEP 1520 CENPKVKEEQ 1530 IDAPPACSEE 1540 SVATPTEIKT ESDTVESV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005849 mRNA cleavage factor complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0000993 RNA polymerase II complex binding
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0031440 regulation of mRNA 3'-end processing
Biological Process GO:0006369 termination of RNA polymerase II transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.