Search Results
Overview
| Uniprot ID | D3ZYK9 |
|---|---|
| Protein Name | Nucleoplasmin-3 |
| Gene Name | Npm3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | LCGILPAKKHRGRP* |
Function
Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM
Protein Sequence
10
MAAGAAAALA
20
FLNQESRARA
30
RGLGGLRVPA
40
PVTMDSFFFG
50
CELSSHTRSF
60
TFKVEEEDDT
70
EHVLALNMLC
80
LTEGAKDECN
90
VVEVVARDHD
100
NQEIAVPVAN
110
LRLSCQPMLS
120
VDDFQLQPPV
130
TFRLKSGSGP
140
VRITGRHQIV
150
CINNDLSEES
160
PDESEDEIKL
170
CGILPAKKHR
GRP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006364 | rRNA processing |
| Biological Process | GO:0009303 | rRNA transcription |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.