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Overview

Uniprot IDD3ZYN2
Protein NameKinesin-like protein KIF21A
Gene NameKif21a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
561 EERSVAGKENNADPD
831 QVRPMSDKVAGKVTR

Function

Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex

Protein Sequence

10 RIRPQLAKEK 20 IEGCHICTSV 30 TPGEPQVFLG 40 KDKAFTFDYV 50 FDIDSQQEQI 60 YTQCIEKLIE 70 GCFEGYNATV 80 FAYGQTGAGK 90 TYTMGTGFDV 100 NIMEEEQGII 110 SRAVKHLFKS 120 IEEKKTSAIK 130 NGVPPPEFKV 140 NAQFLELYNE 150 EVLDLFDTTR 160 DIDAKNKKSN 170 IRIHEDSTGG 180 IYTVGVTTRT 190 VNTEPEMMQC 200 LKLGALSRTT 210 ASTQMNVQSS 220 RSHAIFTIHV 230 CQTRVCPQTD 240 AENVTDNKMV 250 SESPQMNEFE 260 TLTAKFHFVD 270 LAGSERLKRT 280 GATGERAKEG 290 ISINCGLLAL 300 GNVISALGDK 310 SKRATHVPYR 320 DSKLTRLLQD 330 SLGGNSQTIM 340 IACVSPSDRD 350 FMETLNTLKY 360 ANRARNIKNK 370 VMVNQDRASQ 380 QINALRSEIT 390 RLQMELMEYK 400 TGKRIIDEEG 410 VESINDMFHE 420 NAMLQTENNN 430 LRVRIKAMQE 440 TVDALRARIT 450 QLVSEQANQV 460 LARAGEGNEE 470 ISNMIHSYIK 480 EIEDLRAKLL 490 ESEAVNENLR 500 KSLTRATARS 510 PFFSASSAFS 520 STILSSDKET 530 IEIIDLAKKD 540 LEKLKRKEKR 550 KKKRLQKLEE 560 SSREERSVAG 570 KENNADPDQE 580 KKEEKGVSEK 590 ESSEVDVDEN 600 QEASDHEDEE 610 DEEEEDEEED 620 DIEGEESSDE 630 SDSESDEKAN 640 YQADLANITC 650 EIAIKQKLID 660 ELENSQKRLQ 670 TLKKQYEEKL 680 MMLQHKIRDT 690 QLERDQVLQN 700 LGSVESYSEE 710 KAKKVKCEYE 720 KKLHAMNKEL 730 QRLQTAQKEH 740 ARLLKNQSQY 750 EKQLKKLQQD 760 VTEMKKTKVR 770 LMKQMKEEQE 780 KARLTESRRN 790 REIAQLKKDQ 800 RKRDHQLRLL 810 EAQKRNQEVV 820 LRRKTEEVTA 830 LRRQVRPMSD 840 KVAGKVTRKL 850 SSSESPTPDA 860 GSSVTSGEAD 870 ASRPGTQQKM 880 RIPVARVQAL 890 PTPTTNGTRK 900 RYQRKGFTGR 910 VFTSKTARMK 920 WQLLERRVTE 930 IIMQKMTISN 940 MEADMNRLLR 950 QREELTKRRE 960 KLSKRREKIA 970 KESGEGDKNL 980 VNISEEMESL 990 TANIDYINDS 1000 IADCQANIMQ 1010 MEEAKEEGET 1020 LDVTAVINAC 1030 TLTEARYLLD 1040 HFLSMGINKG 1050 LQAAQKEAQI 1060 KVLEGRLKQT 1070 EITSATQNQL 1080 LFHMLKEKAE 1090 LNPELDALLG 1100 NALQAPSFQP 1110 KRDEEDSSEE 1120 DGPLHSPGSE 1130 GSTLSSDLMK 1140 LCGEVKPKNK 1150 ARRRTTTQME 1160 LLYADSSEVA 1170 SDTSAGDASL 1180 PGPLTPVAEG 1190 QETGMNTETS 1200 VPSARDKELL 1210 PPSGLPPKIG 1220 SISRQPSVSE 1230 KKVPEPSPVT 1240 RRKAYEKADK 1250 AKTKEQKHSD 1260 SGASETSLSP 1270 PSSPPSRPRN 1280 ELNVFNRLTV 1290 SQGSAPVQQD 1300 KSDESDPSLS 1310 EVHRGIINPF 1320 PACRGIRASF 1330 LQCVHVAEGH 1340 TKAVLCVDST 1350 DDLLFTGSKD 1360 RTCKVWNLVT 1370 GQEIMSLGVH 1380 PNNVVSVKYC 1390 NYTSLVFTVS 1400 TSYIKVWDIR 1410 ESAKCIRTLT 1420 SSGQVTLGEA 1430 CSASTSRTVA 1440 IPSGESQINQ 1450 IALNPTGTFL 1460 YAASGNAVRM 1470 WDLKRFQSTG 1480 KLTGHLGPVM 1490 CLTVDQISNG 1500 QDLIITGSKD 1510 HYIKMFDVTE 1520 GALGTVSPTH 1530 NFEPPHYDGI 1540 EALAIQGDNL 1550 FSGSRDNGIK 1560 KWDLAQKGLL 1570 QQVPNAHKDW 1580 VCALGLVPGH 1590 PILLSGCRGG 1600 ILKLWNVDTF 1610 VPVGEMRGHD 1620 SPINAISVNS 1630 THVFTAADDR 1640 TVRIWKAHNL 1650 QDGQISDTGD PGEDSTSN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030425 dendrite
Cellular Component GO:0030426 growth cone
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0007018 microtubule-based movement

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.