Overview
| Uniprot ID | D3ZYR1 |
|---|
| Protein Name | F-BAR domain only protein 2 |
|---|
| Gene Name | Fcho2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 475 |
RPKLTSGKLSGINEI |
Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor (By similarity)
Protein Sequence
10
MVMAHFVENF
20
WGEKNNGFDV
30
LYHNMKHGQI
40
STKELADFVR
50
ERATIEEAYS
60
RSMTKLAKSA
70
SNYSQLGTFA
80
PVWDVFKTST
90
EKLANCHLDL
100
VRKLQELIKE
110
VQKYGEEQVK
120
SHKKTKEEVA
130
GTLEAVQAIQ
140
NITQALQKSK
150
ENYNAKCVEQ
160
ERLKKEGATP
170
REIEKAAVKS
180
KKATDTYKLY
190
VEKYALTKAD
200
FEQKMTETAQ
210
KFQDIEETHL
220
IHIKEIIGSL
230
SNAIKEIHLQ
240
IGQVHEEFIN
250
NMANTTIESL
260
IQKFAESKGT
270
GKERPGLIEF
280
EECDPASAVE
290
GIKPRKRKTF
300
ALPGIIKKEK
310
DAESVECPDA
320
DSLNIPDVDE
330
EGFSIKPEAN
340
QNDTKENHFY
350
SSSDSDSEDE
360
EPKRYRIEIK
370
PVHPNNVHHT
380
MASLDELKVS
390
IGNITLSPAV
400
SRHSPVQMNR
410
NSSNEELTKS
420
KPSSLPTEKG
430
TNDLLAWDPL
440
FGSSLESSSA
450
PLTSSSSARP
460
TTPLSLGTIV
470
PPPRPASRPK
480
LTSGKLSGIN
490
EIPRPFSPPI
500
TSNTSPPPTA
510
PLARAESSSS
520
ISSSASLSAA
530
NTPTVGVSRG
540
PSPVSLGNQD
550
TLPVAIALTE
560
SVNAYFKGAD
570
PTKCIVKITG
580
DVTISFPSGI
590
IKVFTSNPSP
600
AVLCFRVKNI
610
SRLEQILPNS
620
QLVFSDPSQC
630
DSNTKDFWMN
640
MQAVTVYLKK
650
LSEQNPAASY
660
YNVDVLKYQV
670
SSNGIQSTPL
680
NLATYWKCSA
690
STTDLRVDYK
700
YNPEAMVAPS
710
VLSNIQVVVP
720
VDGGVTNMQS
730
LPPAIWNAEQ
740
MKAFWKLSGI
750
SEKSDSGGSG
760
SLRAKFDLSE
770
GPSKPATLAV
780
QFLSEGNTLS
790
GVDIELVGTG
800
YRLSLVKKRF
ATGRYLADC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0030136 |
clathrin-coated vesicle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Biological Process |
GO:0048268 |
clathrin coat assembly |
| Biological Process |
GO:0072583 |
clathrin-dependent endocytosis |
| Biological Process |
GO:0010324 |
membrane invagination |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.