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Overview

Uniprot ID	D3ZZ99
Protein Name	Alpha-adducin
Gene Name	Add1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
140	SDSIAYDKGEKLLRC

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin

Protein Sequence

10 MNGDTRAAVV 20 TSPPPTTAPH 30 KERYFDRVDE 40 NNPEYLRERN 50 MAPDLRQDFN 60 MMEQKKRVSM 70 ILQSPAFCEE 80 LESMIQEQFK 90 KGKNPTGLLA 100 LQQIADFMTA 110 SVPNVYPAAP 120 QGGMAALNMS 130 LGMVTPVNDL 140 RGSDSIAYDK 150 GEKLLRCKLA 160 AFYRLADLFG 170 WSQLIYNHIT 180 TRVNSEQEHF 190 LIVPFGLLYS 200 EVTASSLVKV 210 NLQGDIVDRG 220 STNLGVNQAG 230 FTLHSAIYAA 240 RPDAKCIVHI 250 HTPAGAAVSA 260 MKCGLLPISP 270 EALSLGEVAY 280 HDYHGILVDE 290 EEKILIQKNL 300 GPKSKVLILR 310 NHGLVSVGES 320 VEEAFFYIHN 330 LVVACEIQVR 340 TLASAGGPDN 350 LVLLDPGKYK 360 AKSRSPGTPA 370 GEGSGSPPKW 380 QIGEQEFEAL 390 MRMLDNLGYR 400 TGYPYRYPAL 410 RERSKKYSDV 420 EVPASVTGHS 430 FASDGDSGTC 440 SPLRHSFQKQ 450 QREKTRWLNS 460 GRGDDASEEG 470 QNGSSPKSKT 480 KPPNAYASCP 490 PHGLLHWTKE 500 DGHRTSTSAV 510 PNLFVPLNTN 520 PKEVQEMRNK 530 IREQNLQDIK 540 TAGPQSQVLC 550 GVMMDRSLVQ 560 DAPLSDCTET 570 IEGLERTEQT 580 FSPAKSVSFR 590 KGELVTASKA 600 IIEKEYQPHV 610 IVSTTGPNPF 620 NTLTDRELEE 630 YRREVERKQK 640 GSEENLDETR 650 EQKEKSPPDQ 660 SAVPNTPPST 670 PVKLEGGLPQ 680 EPTSRDGSDA 690 TTSKPTPPDL 700 SPDEPSEALA 710 FPTVAEEAHA 720 SPDTTQPLAE 730 ADPEPASASA 740 PGAEEVASPA 750 TEEGSPMDPG 760 SDGSPGKSPS 770 KKKKKFRTPS 780 FLKKSKKKSD S

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0007010	cytoskeleton organization
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005516	calmodulin binding
Biological Process	GO:0051130	positive regulation of cellular component organization
Biological Process	GO:0051094	positive regulation of developmental process
Biological Process	GO:0032535	regulation of cellular component size
Biological Process	GO:2000026	regulation of multicellular organismal development

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.