Search Results
Overview
| Uniprot ID | D3ZZC1 |
|---|---|
| Protein Name | Thioredoxin domain-containing protein 5 |
| Gene Name | Txndc5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 136 | KPGQEAVKYQGPRDF |
Function
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds
Protein Sequence
10
MPPRPGRLFQ
20
PLAGLPALAT
30
LLLLLGARKG
40
ARAQEVEADS
50
GVEQDPHAKH
60
LYTADMFTHG
70
IQSAAHFVMF
80
FAPWCGHCQR
90
LQPTWNDLGD
100
KYNSMEDAKV
110
YVAKVDCTAN
120
SDVCSAQGVR
130
GYPTLKFFKP
140
GQEAVKYQGP
150
RDFETLENWM
160
LQTLNEEPAT
170
PEPEAEPPRA
180
PELKQGLYEL
190
SANNFELHVS
200
QGNHFIKFFA
210
PWCGHCKALA
220
PTWEQLALGL
230
EHSETVKIGK
240
VDCTQHYAVC
250
SEHQVRGYPT
260
LLWFRDGKKV
270
DQYKGKRDLE
280
SLRDYVQSQL
290
QGSEAAPETV
300
EPSEAPVLAA
310
EPPGDKGTVL
320
ALTEKSFEDT
330
IAQGITFVKF
340
YAPWCGHCKN
350
LAPTWEELSK
360
KEFPGLADVT
370
IAEVDCTAER
380
GVCSKYSVRG
390
YPTLLLFRGG
400
EKVGEHNGGR
410
DLDSLHSFVL
RQAKDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Biological Process | GO:0006457 | protein folding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.