Search Results
Overview
| Uniprot ID | D3ZZC5 |
|---|---|
| Protein Name | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
| Gene Name | Tradd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | SEAYTDPKKKVAIYK |
Function
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A
Protein Sequence
10
MAADQNGHEE
20
WVGSAYLFLE
30
SSMDKVVLSE
40
AYTDPKKKVA
50
IYKALQAALS
60
ESGDSPDVLQ
70
ILKIHCSDPQ
80
LIVQLRFCGR
90
LLCGRFLQAY
100
REGALRTALQ
110
RCMAAALAQE
120
AVRLQLELRA
130
GAEQLDSWLT
140
DEERCLNYIL
150
AQKPDRLRDE
160
ELAELEDEFC
170
KLTCDSTGQG
180
GATQVAPAGS
190
KSLVSSPAEE
200
KPLPAAGQTF
210
LFHGQLIVNR
220
PLNLQDQQTF
230
ARSVGLKWRR
240
VGRSLQRSCR
250
ALRDPALDSL
260
AYEYERDGLY
270
EQAFQLLRRF
280
IQAEGRRATL
290
QRLVEALEEN
300
ELTSLAEDLL
310
GQAEPEGGQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0002947 | tumor necrosis factor receptor superfamily complex |
| Molecular Function | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
| Biological Process | GO:0097191 | extrinsic apoptotic signaling pathway |
| Biological Process | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.