Search Results
Overview
| Uniprot ID | D4A0E8 |
|---|---|
| Protein Name | Protein arginine N-methyltransferase 5 |
| Gene Name | Prmt5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 240 | TSIFLTNKKGFPVLS |
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA)
Protein Sequence
10
MAAMAVGGAG
20
GSRVSSGRDL
30
NCVPEIADTL
40
GAVAKQGFDF
50
LCMPVFHPRF
60
KREFIQEPAK
70
NRPGPQTRSD
80
LLLSGRDWNT
90
LIVGKLSPWI
100
HPDSKVEKIR
110
RNSEAAMLQE
120
LNFGAYLGLP
130
AFLLPLNQED
140
NTNLARVLTN
150
HIHTGHHSSM
160
FWMRVPLVAP
170
EDLRDDVIEN
180
APTAHTEEYS
190
GEEKTWLWWH
200
NFRTLCDYSK
210
RIAVALEIGA
220
DLPSSHVIDR
230
WLGEPIKAAI
240
LPTSIFLTNK
250
KGFPVLSKMQ
260
QRLIFRLLKL
270
EVQFIITGTN
280
HHSEKEFCSY
290
LQYLEYLSQN
300
RPPPNAYELF
310
AKGYEDYLQS
320
PLQPLMDNLE
330
SQTYEVFEKD
340
PIKYSQYQQA
350
IYKCLLDRVP
360
EEEKETNVQV
370
LMVLGAGRGP
380
LVNASLRAAK
390
QAERRIRLYA
400
VEKNPNAVVT
410
LENWQFEEWG
420
SQVTVVSSDM
430
REWVAPEKAD
440
IIVSELLGSF
450
ADNELSPECL
460
DGAQHFLKDD
470
GVSIPGEYTS
480
FLAPISSSKL
490
YNEVRACREK
500
DRDPEAQFEM
510
PYVVRLHNFH
520
QLSAPQPCFT
530
FSHPNRDPMI
540
DNNRYCTLEF
550
PVEVNTVLHG
560
FAGYFETVLY
570
RDITLSIRPE
580
THSPGMFSWF
590
PIFFPIKPIT
600
VHEGQNICVR
610
FWRCSNSKKV
620
WYEWAVTAPV
630
CSSIHNPTGR
SYTIGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0008168 | methyltransferase activity |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0035097 | histone methyltransferase complex |
| Cellular Component | GO:0034709 | methylosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0070888 | E-box binding |
| Molecular Function | GO:0070612 | histone H2AR3 methyltransferase activity |
| Molecular Function | GO:0044020 | histone H4R3 methyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008327 | methyl-CpG binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0016274 | protein-arginine N-methyltransferase activity |
| Molecular Function | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0032922 | circadian regulation of gene expression |
| Biological Process | GO:0006353 | DNA-templated transcription termination |
| Biological Process | GO:0042118 | endothelial cell activation |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0090161 | Golgi ribbon formation |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0045596 | negative regulation of cell differentiation |
| Biological Process | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0018216 | peptidyl-arginine methylation |
| Biological Process | GO:0035246 | peptidyl-arginine N-methylation |
| Biological Process | GO:1904992 | positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| Biological Process | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| Biological Process | GO:0006479 | protein methylation |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.