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Overview

Uniprot IDD4A133
Protein NameV-type proton ATPase catalytic subunit A
Gene NameAtp6v1a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
230 ELEFEGVKEKLSMVQ
250 QVRPVTEKLPANHPL
337 GKVESIMKRTALVAN
423 YERAGRVKCLGNPER
615 LYKLSSMKFKDPVKD
621 MKFKDPVKDGEAKIK

Function

Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity

Protein Sequence

10 MCFKFKSDRA 20 SGSGLGTDSA 30 LRARAGKFST 40 MDFSKLPKIR 50 DEDKESTFGY 60 VHGVSGPVVT 70 ACDMAGAAMY 80 ELVRVGHSEL 90 VGEIIRLEGD 100 MATIQVYEET 110 SGVSVGDPVL 120 RTGKPLSVEL 130 GPGIMGAIFD 140 GIQRPLSDIS 150 SQTQSIYIPR 160 GVNVSALSRD 170 IKWEFIPSKN 180 LRVGSHITGG 190 DIYGIVNENS 200 LIKHKIMLPP 210 RSRGSVTYIA 220 PPGNYDASDV 230 VLELEFEGVK 240 EKLSMVQVWP 250 VRQVRPVTEK 260 LPANHPLLTG 270 QRVLDALFPC 280 VQGGTTAIPG 290 AFGCGKTVIS 300 QSLSKYSNSD 310 VIIYVGCGER 320 GNEMSEVLRD 330 FPELTMEVDG 340 KVESIMKRTA 350 LVANTSNMPV 360 AAREASIYTG 370 ITLSEYFRDM 380 GYHVSMMADS 390 TSRWAEALRE 400 ISGRLAEMPA 410 DSGYPAYLGA 420 RLASFYERAG 430 RVKCLGNPER 440 EGSVSIVGAV 450 SPPGGDFSDP 460 VTSATLGIVQ 470 VFWGLDKKLA 480 QRKHFPSVNW 490 LISYSKYMRA 500 LDEYYDKHFT 510 EFVPLRTKAK 520 EILQEEEDLA 530 EIVQLVGKAS 540 LAETDKITLE 550 VAKLIKDDFL 560 QQNGYTPYDR 570 FCPFYKTVGM 580 LSNMISFYDM 590 ARRAVETTAQ 600 SDNKITWSII 610 REHMGEILYK 620 LSSMKFKDPV 630 KDGEAKIKAD 640 YAQLLEDMQN AFRSLED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0033180 proton-transporting V-type ATPase, V1 domain
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0042592 homeostatic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.