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Overview

Uniprot IDD4A239
Protein NameZinc finger protein 516
Gene NameZfp516
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
274 HICGRRFKEPWFLKN
502 AATTGQGKSSECFEC
511 SECFECGKIFRTYHQ
662 HRHSLDLKMPAFHPR
703 QAGHSKEKLSDLHKE
851 SPLGVTTKAASIPKN
969 APDSLKAKFSPQPQG

Function

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress

Protein Sequence

10 MDRSREAEME 20 LRRGPSPPRA 30 GRSHEVDGDK 40 AACHSCCICG 50 KSFPFQSSLS 60 QHMRKHTGEK 70 PYKCPYCDHR 80 ASQKGNLKIH 90 IRSHRTGTLI 100 QGHEPEVGEA 110 QLGELRVSEG 120 LDGCASPTKS 130 TSACNRVLNG 140 AVPTDGSKIL 150 LRSSRKEAEG 160 AASAQEDAEA 170 MVQCSFCKSR 180 FERKKDLELH 190 VHQAHKPFKC 200 RLCSYVTLRE 210 ESLLSHIERD 220 HITAQVPNGS 230 EACVENGKPE 240 LSPGEFPCEV 250 CGQAFSQTWF 260 LKAHMKKHRG 270 SFDHGCHICG 280 RRFKEPWFLK 290 NHMKAHGPKA 300 GSKNRPKSDL 310 DPIATINNVV 320 QEEVIVTGLS 330 LYEICTKCGN 340 LFTDLDSLNA 350 HNTVHRKVEA 360 SRNPAPAEEG 370 DTEDPPDTKQ 380 FFLQCLNLTP 390 CVAGDVSPSG 400 QAGRRVAELD 410 PVNSYQAWQL 420 ATRGKVAEPA 430 EYLKYGTWDE 440 ALAGDVAFDK 450 DKREYILVSQ 460 EKRKRESDAP 470 STQAPPRKRA 480 SVPGDPMLSG 490 HLDPRPASRP 500 NRRAAATTGQ 510 GKSSECFECG 520 KIFRTYHQMV 530 LHSRVHRRAR 540 RDRDPEGDRA 550 VRARCGSLSE 560 GDSASQPSSP 570 GSACATADSP 580 GLAEEVVDDS 590 GEEAVSEPAS 600 GGQPGHCCSS 610 GEVAPILLSN 620 GDPSHKLGNN 630 LPEEDISEPT 640 VGIATPSVSI 650 LENSSRETTK 660 GPEQHRHSLD 670 LKMPAFHPRQ 680 EASTPERVDF 690 PSSMEIASLQ 700 HTLDSQAGHS 710 KEKLSDLHKE 720 HCGVGKRASA 730 PDLVPLDLSM 740 KSSREDPSSK 750 EASSLQTALV 760 IHPCPYCNHK 770 TYYPEVLWMH 780 KRIWHRISCG 790 SIAPPWTQPS 800 GHKSICSNLA 810 FLARSGRTGP 820 PPALGGKDCQ 830 PLLLARFTRT 840 QVPGGVPGSK 850 GSSSPLGVTT 860 KAASIPKNKE 870 SPSGGPCAPW 880 APGPDGYRQT 890 RAGHGQDPPS 900 AAVQGPLPKP 910 KQEASSRLAP 920 SPGSGGLSRS 930 ATPTPSVITR 940 VGAQPSANSK 950 PVEKLGVPAV 960 GTGFTPPNKH 970 SAPDSLKAKF 980 SPQPQGQPPS 990 KGEGGSPLPP 1000 REAPVKPAQE 1010 LRTLATCAAG 1020 PRGDAALQAP 1030 PGAPPTLHSI 1040 QQEPAAAEGQ 1050 EKRLDILSIF 1060 KYIPKDFATL 1070 YQGWGVSSPG 1080 PEHRGTPRTQ 1090 ARQGDFVCVE 1100 CGKSFHQPSQ 1110 LRAHLRAHTV 1120 VFECDSPRGS 1130 EVHTASTDTP 1140 KQGRDHTAPG 1150 TVPAGPLRKG T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.