Search Results
Overview
| Uniprot ID | D4A3K5 |
|---|---|
| Protein Name | Histone H1.1 |
| Gene Name | H1-1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 29 | KKTRKPAKAAVPRKK |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation
Protein Sequence
10
MSETAPVPQP
20
ASVAPEKPAA
30
TKKTRKPAKA
40
AVPRKKPAGP
50
SVSELIVQAV
60
SSSKERSGVS
70
LAALKKSLAA
80
AGYDVEKNNS
90
RIKLGLKSLV
100
NKGTLVQTKG
110
TGAAGSFKLN
120
KKAESKASTT
130
KVTVKAKASG
140
AAKKPKKTAG
150
AAAKKTVKTP
160
KKPKKPAVSK
170
KTSSKSPKKP
180
KVVKAKKVAK
190
SPAKAKAVKP
200
KAAKVKVTKP
210
KTPAKPKKAA
PKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.