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Overview

Uniprot IDD4A435
Protein NameIntercellular adhesion molecule 5
Gene NameIcam5
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
600 FSCEVDGKPEPRVEC

Function

Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion. Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons

Protein Sequence

10 MPGPSPGLRR 20 TLLGLWAALG 30 LGILGISAVA 40 LEPFWADLQP 50 RVALVERGGS 60 LWLNCSTNCP 70 RPERGGLETS 80 LRRNGTQRGL 90 RWLARQLVDI 100 REPETQPVCF 110 FRCARRTLQA 120 RGLIRTFQRP 130 DRVELVPLPP 140 WQPVGENFTL 150 SCRVPGAGPR 160 ASLTLTLLRG 170 GQELIRRSFV 180 GEPPRARGAM 190 LTATVLARRE 200 DHRANFSCLA 210 ELDLRPHGLG 220 LFANSSAPRQ 230 LRTFAMPPLS 240 PSLIAPRFLE 250 VGSERPVTCT 260 LDGLFPAPEA 270 GVYLSLGDQR 280 LHPNVTLDGE 290 SLVATATATA 300 SEEQEGTKQL 310 MCIVTLGGES 320 RETQENLTVY 330 SFPAPLLTLS 340 EPEAPEGKMV 350 TVSCWAGARA 360 LVTLEGIPAA 370 VPGQPAELQL 380 NVTKNDDKRG 390 FFCDAALDVD 400 GETLRKNQSS 410 ELRVLYAPRL 420 DDLDCPRSWT 430 WPEGPEQTLH 440 CEARGNPEPS 450 VHCARPDGGA 460 VLALGLLGPV 470 TRALAGTYRC 480 TAINGQGQAV 490 KDVTLTVEYA 500 PALDSVGCPE 510 RITWLEGTEA 520 SLSCVAHGVP 530 PPSVSCVRSG 540 KEEVMEGPLR 550 VAREHAGTYR 560 CEAINARGSA 570 AKNVAVTVEY 580 GPSFEELGCP 590 SNWTWVEGSG 600 KLFSCEVDGK 610 PEPRVECVGS 620 EGASEGVVLP 630 LVSSNSGSRN 640 SMTPGNLSPG 650 IYLCNATNRH 660 GSTVKTVVVS 670 AESPPQMDES 680 SCPSHQTWLE 690 GAEATALACS 700 ARGRPSPRVR 710 CSREGAARLE 720 RLQVSREDAG 730 TYLCVATNAH 740 GTDSRTVTVG 750 VEYRPVVAEL 760 AASPPSVRPG 770 GNFTLTCRAE 780 AWPPAQISWR 790 APPGALNLGL 800 SSNNSTLSVA 810 GAMGSHGGEY 820 ECAATNAHGR 830 HARRITVRVA 840 GPWLWVAVGG 850 AAGGAALLAA 860 GAGLAFYVQS 870 TACKKGEYNV 880 QEAESSGEAV 890 CLNGAGGTPG 900 AEGGAETPGT 910 AESPADGEVF AIQLTSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042995 cell projection
Cellular Component GO:0032591 dendritic spine membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0031259 uropod membrane
Molecular Function GO:0005178 integrin binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033631 cell-cell adhesion mediated by integrin
Biological Process GO:0007156 homophilic cell-cell adhesion
Biological Process GO:0006909 phagocytosis
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0051963 regulation of synapse assembly

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.