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Overview

Uniprot IDD4A4J0
Protein NameFACT complex subunit
Gene NameSupt16h
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
497 KRRLTEQKGEQQIQK
504 KGEQQIQKARKSNVS

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)

Protein Sequence

10 MAVTLDKDAY 20 YRRVKRLYSN 30 WRKGEDEYAS 40 IDAIVVSVGV 50 DEEIVYAKST 60 ALQTWLFGYE 70 LTDTIMVFCD 80 DKIIFMASKK 90 KVEFLKQIAN 100 TKGNENANGA 110 PAITLLVREK 120 NESNKSSFDK 130 MIEAIKESKN 140 GKKIGVFSKD 150 KFPGEFMKSW 160 SDCLNKEGFD 170 KVDISAVVAY 180 TIAVKEDGEL 190 NLMKKAASIT 200 SEVFNKFFKE 210 RVMEIVDADE 220 KVRHSKLAES 230 VEKAIEEKKY 240 LAGADPSTVE 250 MCYPPIIQSG 260 GNYNLKFSVV 270 SDKNHMHFGA 280 ITCAMGIRFK 290 SYCSNLVRTL 300 MVDPTQEVQE 310 NYNFLLQLQE 320 ELLKELRHGV 330 KICDVYNSVM 340 DVVKKQKPEL 350 LNKITKNLGF 360 GMGIEFREGS 370 LVINSKNQYK 380 LKKGMVFSIN 390 LGFSDLTNKE 400 GKKPEEKTYA 410 LFIGDTVLVD 420 EDGPATVLTS 430 VKKKVKNVGI 440 FLKNEDDEEE 450 EEEKDEAEDL 460 LGRGSRAALL 470 TERTRNEMTA 480 EEKRRAHQKE 490 LAAQLNEEAK 500 RRLTEQKGEQ 510 QIQKARKSNV 520 SYKNPSLMPK 530 EPHIREMKIY 540 IDKKYETVIM 550 PVFGIATPFH 560 IATIKNISMS 570 VEGDYTYLRI 580 NFYCPGSALG 590 RNEGNIFPNP 600 EATFVKEITY 610 RASNMKAPGE 620 QTVPALNLQN 630 AFRIIKEVQK 640 RYKTREAEEK 650 EKEGIVKQDS 660 LVINLNRSNP 670 KLKDLYIRPN 680 IAQKRMQGSL 690 EAHVNGFRFT 700 SVRGDKVDIL 710 YNNIKHALFQ 720 PCDGEMIIVL 730 HFHLKNAIMF 740 GKKRHTDVQF 750 YTEVGEITTD 760 LGKHQHMHDR 770 DDLYAEQMER 780 EMRHKLKTAF 790 KNFIEKVEAL 800 TKEELEFEVP 810 FRDLGFNGAP 820 YRSTCLLQPT 830 SSALVNATEW 840 PPFVVTLDEV 850 ELIHFERVQF 860 HLKNFDMVIV 870 YKDYSKKVTM 880 INAIPVASLD 890 PIKEWLNSCD 900 LKYTEGVQSL 910 NWTKIMKTIV 920 DDPEGFFEQG 930 GWSFLEPEGE 940 GSDAEDGDSE 950 SEIEDETFNP 960 SEDDYEEEEE 970 DSDEDYSSEA 980 EESDYSKESL 990 GSEEESGKDW 1000 DELEEEARKA 1010 DRESRYEEEE 1020 EQSRSMSRKR 1030 KASVHSSGRG 1040 SNRGSRHSSA PPKKKRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035101 FACT complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006337 nucleosome disassembly

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.