Search Results

Overview

Uniprot ID	D4A5L9
Protein Name	-
Gene Name	Cycsl2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
28	VEKGGKHKTGPNLHG
40	LHGLFGRKTGQAAGF
54	FSYTDANKNKGITWG
74	EYLENPKKYIPGTKM
87	KMIFAGIKKKGERAD

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Protein Sequence

10 MGDVEKGKKI 20 FVQKCAQCHT 30 VEKGGKHKTG 40 PNLHGLFGRK 50 TGQAAGFSYT 60 DANKNKGITW 70 GEDTLMEYLE 80 NPKKYIPGTK 90 MIFAGIKKKG 100 ERADLIAYLK KTTNE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005758	mitochondrial intermembrane space
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen
Biological Process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.