Search Results

Overview

Uniprot IDD4A5Q2
Protein NameStructural maintenance of chromosomes protein
Gene NameSmc2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
613 ALSLVDYKPELQKAM

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MYVKSIILEG 20 FKSYAQRTEV 30 NGFDPLFNAI 40 TGLNGSGKSN 50 ILDSICFLLG 60 ISNLSQVRAS 70 NLQDLVYKNG 80 QAGITKASVS 90 ITFDNSDKKQ 100 SPLGFEAHDE 110 ITVTRQVVIG 120 GRNKYLINGV 130 NANNTRVQDL 140 FCSVGLNVNN 150 PHFLIMQGRI 160 TKVLNMKPPE 170 ILSMIEEAAG 180 TRMYEYKKIA 190 AQKTIEKKEA 200 KLKEIKTILE 210 EEITPTIQKL 220 KEERSSYLEY 230 QKVMREIEHL 240 SRLYIAYQFL 250 LAEDTKERSA 260 GELKEMQDKI 270 LKLQEVLSEN 280 EKKIKALNCE 290 IEELEKRKDK 300 ETGGILRSLE 310 DAFAEAQRVN 320 TKSQSAFDLK 330 KKNLASEETK 340 RKELEKNMAE 350 DSKALAAKEK 360 EVKKLTDGLH 370 GLQEASNKDA 380 EALAAAQQHF 390 NAVSAGLSSN 400 EDGAEATLAG 410 QMMACKNDIS 420 KAQTGAKQAQ 430 MKLKHAQQEL 440 KNKQAEVRKM 450 DSGYKKDQEA 460 FEAVKKVKEK 470 LETEMKKLNY 480 EDNKEERLLE 490 KHRQVSRDIS 500 NLKGTYEALL 510 AKFPNLRFAY 520 KDPEKNWNRN 530 CVKGLVASLI 540 NVKDNSTATA 550 LELVAGERLY 560 NVVVDTEVTG 570 KKLLEKGELK 580 RRYTIIPLNK 590 ISARCIAPET 600 LRVAQNLVGP 610 NNVHVALSLV 620 DYKPELQKAM 630 EFVFGTTFVC 640 NNMDNAKKVA 650 FDKRIMTRTV 660 TLGGDVFDPH 670 GTLSGGARSQ 680 AASILTKFQE 690 LKDVQAELRT 700 KEKELQALEE 710 ELAGLKNVAE 720 KYRQLKQQWE 730 MKTEEGDLLQ 740 TKLQQSSYHK 750 QQEELDALKK 760 TIEESEETLK 770 NTKEIQKKAE 780 EKYEALENKM 790 KNAEAEREKE 800 LKDAQKKLDC 810 AKTKADASSK 820 KMKEKQQEVE 830 AITLELEELK 840 REHASNEQQL 850 DAVNEAIKAY 860 EGQIEIMAAE 870 VAKNKESVNK 880 AQNELMKQKE 890 IISAQDNIIK 900 DKCAEVAKHN 910 LQNNDSQLKI 920 KELDHSISKH 930 KREADDAAAK 940 VSKMLNDYDW 950 INAEKHLFGQ 960 PNSAYDFKTN 970 NPKEAGQRLQ 980 KLQEVKEKLG 990 RNVNMRAMNV 1000 LTEAEERYND 1010 LMKKKRIVEN 1020 DKSKILATIE 1030 DLDQKKNQAL 1040 NIAWQKVNKD 1050 FGSIFSTLLP 1060 GANAMLAPPE 1070 GQTVLDGLEF 1080 KVALGNTWKE 1090 NLTELSGGQR 1100 SLVALSLILS 1110 MLLFKPAPIY 1120 ILDEVDAALD 1130 LSHTQNIGQM 1140 LRTHFTHSQF 1150 IVVSLKEGMF 1160 NNANVLFKTK 1170 FVDGVSTVAR 1180 FTQSQNGRIP 1190 KEAKAKGKGP S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000228 nuclear chromosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0048468 cell development
Biological Process GO:0051301 cell division
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0071707 immunoglobulin heavy chain V-D-J recombination
Biological Process GO:0051383 kinetochore organization
Biological Process GO:0010032 meiotic chromosome condensation
Biological Process GO:0045132 meiotic chromosome segregation
Biological Process GO:0007076 mitotic chromosome condensation
Biological Process GO:1905821 positive regulation of chromosome condensation
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:1905820 positive regulation of chromosome separation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.