Search Results
Overview
| Uniprot ID | D4A5S0 |
|---|---|
| Protein Name | Rho-associated protein kinase |
| Gene Name | Rock1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 999 | ISTERTLKTQAVNKL |
Function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity
Protein Sequence
10
MSTGDSFETR
20
FEKIDNLLRD
30
PKSEVNSDCL
40
LDGLDALVYD
50
LDFPALRKNK
60
NIDNFLSRYK
70
DTINKIRDLR
80
MKAEDYEVVK
90
VIGRGAFGEV
100
QLVRHKSTRK
110
VYAMKLLSKF
120
EMIKRSDSAF
130
FWEERDIMAF
140
ANSPWVVQLF
150
YAFQDDRYLY
160
MVMEYMPGGD
170
LVNLMSNYDV
180
PEKWARFYTA
190
EVVLALDAIH
200
SMGFIHRDVK
210
PDNMLLDKSG
220
HLKLADFGTC
230
MKMNKEGMVR
240
CDTAVGTPDY
250
ISPEVLKSQG
260
GDGYYGRECD
270
WWSVGVFLYE
280
MLVGDTPFYA
290
DSLVGTYSKI
300
MNHKNSLTFP
310
DDNDISKEAK
320
NLICAFLTDR
330
EVRLGRNGVE
340
EIKRHLFFKN
350
DQWAWETLRD
360
TVAPVVPDLS
370
SDIDTSNFDD
380
LEEDKGDEET
390
FPIPKAFVGN
400
QLPFVGFTYY
410
SNRRYLPSAN
420
PSENRSSSNV
430
DKNVQESLQK
440
TIYKLEEQLH
450
NEMQLKDEME
460
QKCRTSNIKL
470
DKIMKELDEE
480
GNQRRNLESA
490
VSQIEKEKML
500
LQHRINEYQR
510
KVEQENEKRR
520
NVENEVSTLK
530
DQLEDLRKAS
540
QSSQLANEKL
550
TQLQKQLEEA
560
NDLLRTESDT
570
AVRLRKSHTE
580
MSKSVSQLES
590
LNRELQERNR
600
MLENSKSQAD
610
KDYYQLQAVL
620
EAERRDRGHD
630
SEMIGDLQAR
640
ITSLQEEVKH
650
LKHNLERVEG
660
ERKEAQDMLN
670
HSEKEKNNLE
680
IDLNYKLKSI
690
QQRLEQEVNE
700
HKVTKARLTD
710
KHQSIEEAKS
720
VAMCEMEKKL
730
KEEREAREKA
740
ENRVVETEKQ
750
CSMLDVDLKQ
760
SQQKLEHLTE
770
NKERLEDAVK
780
SLTLQLEQES
790
NKRILLQSEL
800
KTQAFEADNL
810
KGLEKQMKQE
820
INTLLEAKRL
830
LEFELAQLTK
840
QYRGNEGQMR
850
ELQDQLEAEQ
860
YFSTLYKTQV
870
KELKEEIEEK
880
NRENLRKIQE
890
LQSEKETLST
900
QLDLAETKAE
910
SEQLARGILE
920
EQYFELTQES
930
KKAASRNRQE
940
ITDKDHTVSR
950
LEEANNALTK
960
DIELLRKENE
970
ELNERMRTAE
980
EEYKLKKEEE
990
ISNLKAAFEK
1000
NISTERTLKT
1010
QAVNKLAEIM
1020
NRKDFKIDRK
1030
KANTQDLRKK
1040
EKENRKLQLE
1050
LNQEREKFNQ
1060
MVVKHQKELN
1070
DMQAQLVEEC
1080
THRNELQMQL
1090
ASKESDIEQL
1100
RAKLLDLSDS
1110
TSVASFPSAD
1120
ETDGNLPESR
1130
IEGWLSVPNR
1140
GNIKRYGWKK
1150
QYVVVSSKKM
1160
LFYNDEQDKE
1170
QSSPSMVLDI
1180
DKLFHVRPVT
1190
QGDVYRAETE
1200
EIPKIFQILY
1210
ANEGECRKDI
1220
EVEPVQQGEK
1230
TNFQNHKGHE
1240
FIPTLYHFPA
1250
NCEACAKPLW
1260
HVFKPPPALE
1270
CRRCHVKCHR
1280
DHLDKKEDLI
1290
SPCKVSYDVT
1300
SARDMLLLAC
1310
SQDEQKKWVT
1320
HLVKKIPKNP
1330
PSGFVRASPR
1340
TLSTRSTANQ
1350
SFRKVVKNTS
GKTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0071559 | response to transforming growth factor beta |
| Cellular Component | GO:0032059 | bleb |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0072518 | Rho-dependent protein serine/threonine kinase activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0097746 | blood vessel diameter maintenance |
| Biological Process | GO:0001837 | epithelial to mesenchymal transition |
| Biological Process | GO:0050901 | leukocyte tethering or rolling |
| Biological Process | GO:0022614 | membrane to membrane docking |
| Biological Process | GO:0061157 | mRNA destabilization |
| Biological Process | GO:0051451 | myoblast migration |
| Biological Process | GO:1902430 | negative regulation of amyloid-beta formation |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:1903347 | negative regulation of bicellular tight junction assembly |
| Biological Process | GO:0140058 | neuron projection arborization |
| Biological Process | GO:0090521 | podocyte cell migration |
| Biological Process | GO:1900223 | positive regulation of amyloid-beta clearance |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:1905205 | positive regulation of connective tissue replacement |
| Biological Process | GO:0051894 | positive regulation of focal adhesion assembly |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0110061 | regulation of angiotensin-activated signaling pathway |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:1903140 | regulation of establishment of endothelial barrier |
| Biological Process | GO:0045616 | regulation of keratinocyte differentiation |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0090128 | regulation of synapse maturation |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:1990776 | response to angiotensin |
| Biological Process | GO:0007266 | Rho protein signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.