Search Results

Overview

Uniprot ID	D4A7G0
Protein Name	Zinc finger CCCH domain-containing protein 14
Gene Name	Zc3h14
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
295	VSSVVKVKRFSHDGE
357	EAQESVTKTTNYPAV
597	CKYWPACKNGDECVY

Function

RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells

Protein Sequence

10 SDMNTVLNRK 20 LNNAINEELP 30 DYIMVMVANK 40 KSQDQMTEDL 50 SLFLGNNTIR 60 FTVWLHGVLD 70 KLRSVTTEPS 80 SLKSPDTSIF 90 DSNVPSNKSS 100 FSRGDERRHE 110 AAIPPLAVSS 120 SRPEKRDSRV 130 STSSQEHKST 140 NVRHSYDDGA 150 STRLMSTVKP 160 LREPAPSEDV 170 IDIKPEPDDL 180 IDEDLNFVQE 190 NSLSQKKPTV 200 TLTYGSSRPS 210 IEIYRPPASR 220 NADTGTHLNR 230 PQLQQQQSST 240 HTAKQLDGQS 250 SQVYEAGRLC 260 EPEVLGSVED 270 TYSPFFRNNL 280 DKMNIEEENF 290 RKRKLPVVSS 300 VVKVKRFSHD 310 GEEEEEDEDY 320 GTRVGSLSSS 330 VSVPAKPERR 340 PSLPPSKQAN 350 KNLILKAISE 360 AQESVTKTTN 370 YPAVPQKQTL 380 PVAPRTRTSQ 390 EEVLAEMVQG 400 QNRAPRISPP 410 VKEEEAKGDN 420 AEKIEGTQQR 430 QLLSRLQIDP 440 VTVDTMELSQ 450 DYYDMESMVH 460 ADTRSFILKK 470 PKLSEEIVVT 480 PNQDSGMKTA 490 DALRVLSGHL 500 MQTRDLVQPD 510 KPASPKFIVT 520 LDGVPSPPGY 530 MSDQEEEMCF 540 EGMKPVNQTS 550 ASNKGLRGLL 560 HPQQLHLLSR 570 QLEDPDGSFS 580 NAEMTDLSVA 590 QKPEKLLERC 600 KYWPACKNGD 610 ECVYHHPISP 620 CKAFPNCKFA 630 EKCLFVHPNC 640 KYDAKCTKAD 650 CPFTHMSRRG 660 PVLTPKPAVS 670 SPAPSSNGQL 680 CRYFPACKKM 690 ECPFYHPKHC 700 RFNTQCTRPD 710 CTFYHPTITV 720 PPRHALKWIR PQTR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Molecular Function	GO:0008143	poly(A) binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0043488	regulation of mRNA stability

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.