Search Results
Overview
| Uniprot ID | D4A7J8 |
|---|---|
| Protein Name | U4/U6 small nuclear ribonucleoprotein Prp4 |
| Gene Name | Prpf4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | SSTTTKTKAPDDLVA |
| 44 | KERERLAKGESGILG |
| 52 | GESGILGKEGLKAGI |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)
Protein Sequence
10
MASSRASSTT
20
TKTKAPDDLV
30
APVVKKPHIY
40
YGSLEEKERE
50
RLAKGESGIL
60
GKEGLKAGIE
70
AGNINITSGE
80
VFEIEEHISE
90
RQAEVLAEFE
100
RRKRARQINV
110
STDDSEVKAC
120
LRALGEPITL
130
FGEGPAERRE
140
RLRNILSVVG
150
TDALKKTKKD
160
DEKSKKSKEE
170
YQQTWYHEGP
180
NSLKVARLWI
190
ANYSLPRAMK
200
RLEEARLHKE
210
IPETTRTSQM
220
QELHKSLRSL
230
NNFCSQIGDD
240
RPISYCHFSP
250
NSKMLATACW
260
SGLCKLWSVP
270
DCSLLHTLRG
280
HNTNVGAIVF
290
HPKSTVSLDQ
300
KDVNLASCAA
310
DGSVKLWSLD
320
SDEPVADIEG
330
HTVRVARVMW
340
HPSGRFLGTT
350
CYDRSWRLWD
360
LEAQEEILHQ
370
EGHSMGVYDI
380
AFHQDGSLAG
390
TGGLDAFGRV
400
WDLRTGRCIM
410
FLEGHLKEIY
420
GISFSPNGYH
430
IATGSGDNTC
440
KVWDLRQRRC
450
VYTIPAHQNL
460
VTGVKFEPIH
470
GDFLLTGAYD
480
NTAKIWTHPG
490
WSPLKTLAGH
500
EGKVMGLDIS
510
SDGQLIATCS
520
YDRTFKLWMA
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0097525 | spliceosomal snRNP complex |
| Cellular Component | GO:0071016 | U12-type precatalytic spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0071001 | U4/U6 snRNP |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Molecular Function | GO:0030621 | U4 snRNA binding |
| Molecular Function | GO:0017070 | U6 snRNA binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.