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Overview

Uniprot IDD4A853
Protein NameProtein capicua homolog
Gene NameCic
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1175 PSPKAPQKVKAAIAS
1329 EVTSSGKKMKVRPPP
262 QVKEAHFKAHPDWKW
729 VSLVYSDKKSAAATS

Function

Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development

Protein Sequence

10 MYSAHRPLIP 20 ASGAASRGLG 30 MFVWTNVEPR 40 SVAVFPWHSL 50 VPFLAPSQPD 60 PSVQPSEAQQ 70 PASHPVASNQ 80 SKEPAESAAV 90 AHEQPPGGTG 100 GADPGRPPGA 110 TCPESPGPGP 120 PLTLGGVDPG 130 KSLPPTTEEE 140 APGPPGEPRL 150 DSETESDHDD 160 AFLSIMSPEI 170 QLPLPPGKRR 180 TQSLSALPKE 190 RDSSSEKDGR 200 SPNKREKDHI 210 RRPMNAFMIF 220 SKRHRALVHQ 230 RHPNQDNRTV 240 SKILGEWWYA 250 LGPKEKQKYH 260 DLAFQVKEAH 270 FKAHPDWKWC 280 NKDRKKSSSE 290 AKPASLGLAG 300 GHKETRERSM 310 SETGTAAAPG 320 VSSELLSAAA 330 QTLLSSDTKA 340 PGSGPCGAER 350 LHAVGGPGSA 360 RPRAFSHSGV 370 HSLDGGEVDS 380 QALQELTQMV 390 SGPTSFSGPK 400 PSPQYGAPGS 410 FAAPGEGGNL 420 ATSGRPPLLP 430 SRASRSQRAA 440 SEDMTSDEER 450 MVICEEEGDD 460 DVIADDSFGT 470 TDIDLKCKER 480 VTDSESGDSS 490 GEDPEGNKGF 500 GRKVFSPVIR 510 SSFTHCRPTL 520 DPEPPGPPDP 530 PAAFSKGYGP 540 TPSSSSSPAS 550 TSVSVSTSFS 560 LGSGTFKTQE 570 SGQGSTAVPL 580 RPPPPGAGGP 590 TTPSKATRFL 600 PTDSATFRRK 610 RPESVGSLEA 620 PGSSVIAAPP 630 SGGGNILQTL 640 VLPPSKEDRE 650 GTRVPSAPAP 660 SLAYGAPAAP 670 LCRPAATMVT 680 NVVRPVSSTP 690 VPIASKPFPT 700 SGRAEASSND 710 TVGARTEMGT 720 GSRVPGGSPL 730 GVSLVYSDKK 740 SAAATSPAPH 750 LVAGPLLGTV 760 GKAPATVTNL 770 LVGTPGYGAP 780 ASPAVQFIAQ 790 GAPGSATPAG 800 SGASAGSGPN 810 GPVPLGILQP 820 GALGKAGGIT 830 QVQYILPTLP 840 QQLQVAPAPA 850 PAPGTKAAAP 860 SGPAPTTSIR 870 FTLPPGTSTN 880 GKVLAATAPT 890 AGIPILQSVP 900 SAPPPKAQSV 910 SPVQATPSGG 920 SAQLLPGKVL 930 VPLAAPSMSV 940 RGGGAGQPLP 950 LVSSPFSVPV 960 QNGAQQPSKI 970 IQLTPVPVST 980 PSGLVPPLSP 990 ATMPGPTSQP 1000 QKVLLPSSTR 1010 ITYVQSAGGH 1020 TLPLGTSSAC 1030 SQTGTVTSYG 1040 PASSVALGFT 1050 SLGPSGPAFV 1060 QPLLSAGQAP 1070 LLAPGQVGVS 1080 PVPSPQLPPA 1090 CTAPGGPVIT 1100 AFYPGSPAPT 1110 SAPLGPPSQA 1120 PPSLVYTVAT 1130 STTPPAAAIL 1140 PKGPPASATA 1150 TPAPTSPFPS 1160 ATAGSMTYSL 1170 VAPKAQRPSP 1180 KAPQKVKAAI 1190 ASIPVGSFES 1200 GTTGRTGPTP 1210 RQSLDSGVAR 1220 EPAAPESELE 1230 GQPTPPAPPP 1240 PTETWPPTAR 1250 SSPPPPLPAE 1260 ERPGTKGPET 1270 ASKFPSSSSD 1280 WRVPGLGLES 1290 RGEPPTPPSP 1300 APAPATGPSG 1310 SSSGSSEGSS 1320 GRAAGDTPER 1330 KEVTSSGKKM 1340 KVRPPPLKKT 1350 FDSVDNRVLS 1360 EVDFEERFAE 1370 LPEFRPEEVL 1380 PSPTLQSLAT 1390 SPRAILGSYR 1400 KKRKNSTDLD 1410 SAPEDPTSPK 1420 RKMRRRSSCS 1430 SEPNTPKSAK 1440 CEGDIFTFDR 1450 TGTETEDVLG 1460 ELEYEKVPYS 1470 SLRRTLDQRR 1480 ALVMQLFQDH 1490 GFFPSAQATA 1500 AFQARYADIF 1510 PSKVCLQLKI 1520 REVRQKIMQA 1530 ATPTEQPPGA 1540 EASLPGPPPT 1550 GMAATPVPTP 1560 SPAGGPDPTS 1570 PGSDSGTAQV 1580 APPLPPPPEP 1590 GPGQPGWEGA 1600 PQPSPPPSGP STAATGR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0007420 brain development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007612 learning
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0007613 memory
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0035176 social behavior

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.