Search Results
Overview
| Uniprot ID | D4A944 |
|---|---|
| Protein Name | U5 small nuclear ribonucleoprotein 40 kDa protein |
| Gene Name | Snrnp40 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 313 | DVRPFAPKERCVKIF |
| 50 | MIEQQKRKGPELPLV |
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Protein Sequence
10
MLEIDWLLSS
20
GSSGGRTQLK
30
PIAQRLLQAA
40
RLLAAPRVVV
50
AAMIEQQKRK
60
GPELPLVPVK
70
RPRHELLLGA
80
AGSGPGAGQQ
90
QATPGALLQT
100
GPPRCSSLQA
110
PIMLLSGHEG
120
EVYCCKFHPN
130
GSTLASAGFD
140
RLILLWSVYG
150
DCDNYATLKG
160
HSGAVMELHY
170
NTDGSMLFSA
180
STDKTVAVWD
190
SETGERVKRL
200
KGHTSFVNSC
210
YPARRGPQLV
220
CTGSDDGTVK
230
LWDIRKKAAI
240
QTFQNTYQVL
250
AVTFNDTSDQ
260
IISGGIDNDI
270
KVWDLRQNKL
280
TYTMRGHADS
290
VTGLSLSSEG
300
SYLLSNAMDN
310
TVRVWDVRPF
320
APKERCVKIF
330
QGNVHNFEKN
340
LLRCSWSPDG
350
SKIAAGSADR
360
FVYVWDTTSR
370
RILYKLPGHA
380
GSINEVAFHP
390
DEPIILSASS
400
DKRLYMGEIQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0071014 | post-mRNA release spliceosomal complex |
| Cellular Component | GO:0071020 | post-spliceosomal complex |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071018 | U12-type catalytic step 2 spliceosome |
| Cellular Component | GO:0071016 | U12-type precatalytic spliceosome |
| Cellular Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005682 | U5 snRNP |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0000375 | RNA splicing, via transesterification reactions |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.