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Overview

Uniprot ID	D4A9B0
Protein Name	S1 RNA-binding domain-containing protein 1
Gene Name	Srbd1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
72	KQGPRVKKSAQQVHD

Function

DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure. During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation. Also contributes to the regulation of nucleus pulposus cell senescence

Protein Sequence

10 MIAMPSLRKR 20 TKIQTENAEP 30 RDECSSFSEL 40 SSGSEEDNKE 50 DSIWEPQKKV 60 LRNRRRPASK 70 GSKRKQGPRV 80 KKSAQQVHDI 90 SKDVAVKEEL 100 NSPVAIVNAN 110 LEEENQKLHT 120 TNTLKTAAKK 130 QKNAGHGAKK 140 RLKVDEETNQ 150 ASPFEGGESN 160 VEAPSTSEDR 170 DMCKKESEDS 180 FTFEQSPLKR 190 IKTESCPQGR 200 PARVPGASDI 210 KEEVEMNWDI 220 VQVLSERTNI 230 EPWICANIIR 240 LFNDDNTIPF 250 IVRYRKELIN 260 NLDADFLREV 270 RQTLDELRDV 280 AKKVHSRIQK 290 IKKEGKMSEC 300 LLQALLNCKT 310 FEELEHVSAP 320 YKMGSKGTKA 330 QRAKQLGLEG 340 AAWTLLENPG 350 QLNLPSYIRP 360 DVKGLSELKD 370 IETGVQHILA 380 DMIAKDKDTL 390 DFIRDLCKHR 400 YICIQSSLAK 410 VSSKKVNEKE 420 VDKFQLYQNF 430 SCNIRNIHHH 440 QILAINRGEN 450 LKILTVKVNI 460 SDGVKNEFCR 470 WCIQNRWRPR 480 GFARPELMKI 490 LHNSLDDSFK 500 RLIVPLLCRE 510 LRAKLTSDAE 520 KQSVMMFGQN 530 LRQLLLTSPV 540 PGRTLMGVDP 550 GYKHGCKLAI 560 ISPTSQILHT 570 DVVYLHCGQG 580 FREAEKIKRL 590 LLNFNCNTVV 600 IGNGTACRET 610 EAYFADLIMK 620 NYFAPLDVVY 630 CIVSEAGASI 640 YSVSPEANKE 650 MPGLDPNLRS 660 AVSIARRVQD 670 PLAELVKFDP 680 KHIGVGMYQH 690 DVSQTLLKAT 700 LDSVVEECVS 710 FVGVDINICS 720 EVLLRHIAGL 730 NANRAKNIIE 740 WREKNGPFIN 750 REQLKKVKGL 760 GPKSFQQCAG 770 FVRVNQDYIR 780 TFCSGQHTDS 790 SGQSQEAAMV 800 TKEKPGKKKN 810 KADVALTPNP 820 LDETCIHPES 830 YDIAVRFLSF 840 IGGTLYEIGK 850 PEMQQKINSS 860 LGKEGIEKTA 870 ERLQTTAHTL 880 QVIIDGLSQP 890 KTFDIRTDFD 900 KPDFKRSIVC 910 LADLQVGTIL 920 TGKVENATLF 930 GVFVDIGVGK 940 AGLIPIRFIT 950 EAKLSKTKKR 960 RSLGLGPGEK 970 VEVKVLSVDI 980 PRSRISLDLL RVL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003735	structural constituent of ribosome
Biological Process	GO:0006139	nucleobase-containing compound metabolic process
Biological Process	GO:0006412	translation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.