Search Results
Overview
| Uniprot ID | D4AAL7 |
|---|---|
| Protein Name | Large ribosomal subunit protein uL23 |
| Gene Name | Rpl23al9 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | KEAPAPPKAEAKAKA |
| 7 | *MAPKAKKEAPAPPK |
Function
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination
Protein Sequence
10
MAPKAKKEAP
20
APPKAEAKAK
30
ALKAKKAVLK
40
GVHSHKKKKT
50
RTSPTFRRPK
60
TLRLRRQPKY
70
PRKSAPRRNK
80
LDHYAIIKFP
90
LTTESAMKKI
100
EDNNALVFTV
110
DVKANKHQVK
120
QAVKKLYDID
130
VAKVNTMIRP
140
DGEKKAYVHL
150
APDYDALDVA
NKIGII
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0022625 | cytosolic large ribosomal subunit |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0006412 | translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.