Search Results
Overview
| Uniprot ID | D4AAT7 |
|---|---|
| Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Gene Name | Naxd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | IVPALTSKKHKGQDG |
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Protein Sequence
10
MAVCPYGAAA
20
VVMALLSAAI
30
AFHCSPLLAV
40
LQRALSLHTA
50
HATKDMDNLF
60
QLVRNIVPAL
70
TSKKHKGQDG
80
RIGIVGGCQE
90
YTGAPYFAGI
100
SALKVGADLT
110
HVFCAREAAP
120
VIKSYSPELI
130
VHPVLDSSDA
140
VEEVEKWLPR
150
LHALVVGPGL
160
GRDDLLLNNV
170
RGILESTKAR
180
DIPVVIDADG
190
LWLIAQRPAL
200
VHGYQKAVLT
210
PNHVEFSRLW
220
DAVLSSPMDT
230
SNHSGSVLKL
240
SQALGNITIV
250
QKGEQDLISN
260
GQQVLVCNQE
270
GSSRRCGGQG
280
DLLSGSLGVM
290
AHWALRAGPE
300
KTNGSSPLLV
310
AAWGACTLTR
320
ECNHLAFQKY
330
GRSTTTTDMI
340
AEVGAAFSKL
FTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity |
| Biological Process | GO:0110051 | metabolite repair |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.