Search Results

Overview

Uniprot IDD4AAX6
Protein NamePhosphoinositide phospholipase C
Gene NamePlch2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
966 GSSSPRGKAPAGEAT

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain

Protein Sequence

10 WFLQLAPGGL 20 ERCMSAMQEG 30 TQMVKLRGSS 40 KGLVRFYYLD 50 EHRSCLRWRP 60 SRKNEKAKIS 70 IDSIQEVSEG 80 RQSEIFQRYP 90 DSSFDPNCCF 100 SIYYGSHRES 110 LDLVSPSSEE 120 ARTWVTGLRY 130 LMAGISDEDS 140 LARRQRTRDQ 150 YPWWLKQTFD 160 EADKNGDGSL 170 SISEVLQLLH 180 KLNVNLPRQR 190 VKQMFREADT 200 DDHQGTLGFE 210 EFCAFYKMMS 220 TRRDLYLLML 230 TYSNHKDHLD 240 ASDLQRFLEV 250 EQKMSGVTLE 260 SCQSIIEQFE 270 PCLENKSKGV 280 LGIDGFTNYT 290 RSPAGDIFNP 300 EHHRVHQDMT 310 QPLSHYFITS 320 SHNTYLVGDQ 330 LMSQSRVDMY 340 AWVLQAGCRC 350 VEVDCWDGPD 360 GEPIVHHGYT 370 LTSKILFKDV 380 IETINKYAFI 390 KNEYPVILSI 400 ENHCSVVQQK 410 KMAQYLTDIL 420 GDKLDLSSVS 430 GEDATMLPSP 440 QMLKGKILVK 450 GKKLPANISE 460 DAEEGEVSDE 470 DSADEIEDDC 480 KLLNGDASTN 490 RKRVENIAKK 500 KLDSLIKESK 510 IRDCEDPNDF 520 TVSTLSPSGK 530 LGHKAEAKKA 540 QSKAEEDVES 550 GEDTGVSRRN 560 SRLLMSSFSK 570 RKKKGSKIKK 580 VASVEEGDES 590 LDSPGSQSRG 600 TARQKKTMKL 610 SRALSDLVKY 620 TKSVGTHDVE 630 MEVVSSWQVS 640 SFSETKAHQI 650 LQQKPAQYLR 660 FNQHQLSRIY 670 PSSYRVDSSN 680 YNPQPFWNAG 690 CQMVALNYQS 700 EGRMLQLNRA 710 KFSANGGCGY 720 VLKPQCMCQG 730 VFNPNSEDPL 740 PGQLKKQLAL 750 RIISGQQLPK 760 PRDSVLGDRG 770 EIIDPFVEVE 780 VIGLPVDCSK 790 EQTRVVDDNG 800 FNPMWEETLV 810 FTVHMPEIAL 820 VRFLVWDHDP 830 IGRDFIGQRT 840 LAFSSMMPGY 850 RHVYLEGMEE 860 ASIFVHVAVS 870 DISGKVKQTL 880 GLKGLFLRGP 890 KPGSLDSHAA 900 GQPLPRPSVS 910 QRLLRRTASA 920 PTKSQKPSRK 930 GFPELALGTQ 940 DAGSEGAADD 950 VAPPSPNPAL 960 EAPTQERSGS 970 SSPRGKAPAG 980 EATEERTPAQ 990 VRSPRAPEGP 1000 GPAGMAATCM 1010 KCVVGSCTGM 1020 DVEGLRREQQ 1030 PSPGPAGSRT 1040 AISQQPRARV 1050 DSLGGPCCSL 1060 SPRATPGRSR 1070 EAPKGPRARR 1080 QGPGGSSVSS 1090 DSSSPDSPGS 1100 PKVAPCQPEG 1110 AHRQQGALQG 1120 EMNALFVQKL 1130 EEIRSHSPMF STVRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0016042 lipid catabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.