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Overview

Uniprot IDD4ABN3
Protein NameSynaptojanin-1
Gene NameSynj1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1140 RSPAPARKEFGGVGA
1226 LTPESQSKPLETSKG
169 QSLHLHLKHYGVNCD
346 VKGGKAEKLHSVLKP
449 GTGALEGKAKAGKLK
518 TLQSASSKVLKNMCE
580 GIQEFQDKRSKPTDI

Function

Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2

Protein Sequence

10 MAFSKGFRIY 20 HKLDPPPFSL 30 IVETRHKEEC 40 LMFESGAVAV 50 LSSAEKEAIK 60 GTYAKVLDAY 70 GLLGVLRLNL 80 GDTMLHYLVL 90 VTGCMSVGKI 100 QESEVFRVTS 110 TEFISLRVDA 120 SDEDRISEVR 130 KVLNSGNFYF 140 AWSASGVSLD 150 LSLNAHRSMQ 160 EHTTDNRFFW 170 NQSLHLHLKH 180 YGVNCDDWLL 190 RLMCGGVEIR 200 TIYAAHKQAK 210 ACLISRLSCE 220 RAGTRFNVRG 230 TNDDGHVANF 240 VETEQVIYLD 250 DCVSSFIQIR 260 GSVPLFWEQP 270 GLQVGSHRVR 280 MSRGFEANAP 290 AFDRHFRTLK 300 DLYGKQIVVN 310 LLGSKEGEHM 320 LSKAFQSHLK 330 ASEHASDIHM 340 VSFDYHQMVK 350 GGKAEKLHSV 360 LKPQVQKFLD 370 YGFFYFDGSA 380 VQRCQSGTVR 390 TNCLDCLDRT 400 NSVQAFLGLE 410 MLAKQLEALG 420 LAEKPQLVTR 430 FQEVFRSMWS 440 VNGDSISKIY 450 AGTGALEGKA 460 KAGKLKDGAR 470 SVTRTIQNNF 480 FDSSKQEAID 490 VLLLGNTLNS 500 DLADKARALL 510 TTGSLRVSEQ 520 TLQSASSKVL 530 KNMCENFYKY 540 SKPKKIRVCV 550 GTWNVNGGKQ 560 FRSIAFKNQT 570 LTDWLLDAPK 580 LAGIQEFQDK 590 RSKPTDIFAI 600 GFEEMVELNA 610 GNIVNASTTN 620 QKLWAVELQK 630 TISRDNKYVL 640 LASEQLVGVC 650 LFVFIRPQHA 660 PFIRDVAVDT 670 VKTGMGGATG 680 NKGAVAIRML 690 FHTTSLCFVC 700 SHFAAGQSQV 710 KERNEDFVEI 720 ARKLSFPMGR 730 MLFSHDYVFW 740 CGDFNYRIDL 750 PNEEVKELIR 760 QQNWDSLIAG 770 DQLINQKNAG 780 QIFRGFLEGK 790 VTFAPTYKYD 800 LFSEDYDTSE 810 KCRTPAWTDR 820 VLWRRRKWPF 830 DRSAEDLDLL 840 NASFQDESKI 850 LYTWTPGTLL 860 HYGRAELKTS 870 DHRPVVALID 880 IDIFEVEAEE 890 RQKIYKEVIA 900 VQGPPDGTVL 910 VSIKSSAQEN 920 TFFDDALIDE 930 LLQQFAHFGE 940 VILIRFVEDK 950 MWVTFLEGSS 960 ALNVLSLNGK 970 ELLNRTITIT 980 LKSPDWIKTL 990 EEEMSLEKIS 1000 VTLPSSTSST 1010 LLGEDAEVSA 1020 DFDMEGDVDD 1030 YSAEVEELLP 1040 QHLQPSSSSG 1050 LGTSPSSSPR 1060 TSPCQSPTAP 1070 EYSAPSLPIR 1080 PSRAPSRTPG 1090 PLSSQGAPVD 1100 TQPAAQKESS 1110 QTIEPKRPPP 1120 PRPVAPPARP 1130 APPQRPPPPS 1140 GARSPAPARK 1150 EFGGVGAPPS 1160 PGVTRREMEA 1170 PKSPGTARKD 1180 NIGRNQPSPQ 1190 AGLAGPGPSG 1200 YGAARPTIPA 1210 RAGVISAPQS 1220 QARVSAGRLT 1230 PESQSKPLET 1240 SKGPAVLPEP 1250 LKPQAAFPPQ 1260 PSLPTPAQKL 1270 QDPLVPIAAP 1280 MPPSIPQSNL 1290 ETPPLPPPRS 1300 RSSQSLPSDS 1310 SPQLQQEQPT G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030118 clathrin coat
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0052745 inositol phosphate phosphatase activity
Molecular Function GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0046856 phosphatidylinositol dephosphorylation
Biological Process GO:0048259 regulation of receptor-mediated endocytosis

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.