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Overview

Uniprot ID	D4ACS0
Protein Name	Protein phosphatase 1 regulatory subunit
Gene Name	Ppp1r12a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
320	PQKTFKNKETLIIEP
420	KFPTSTTKISPKEEE
442	SWRLGLRKTGSYGAL
758	NEQERQSDTEDGSSK
868	ADRSLLEMEKRERRA

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity

Protein Sequence

10 MKMADAKQKR 20 NEQLKRWIGS 30 ETDLEPPVVK 40 RQKTKVKFDD 50 GAVFLAACSS 60 GDTDEVLKLL 70 HRGADINYAN 80 VDGLTALHQA 90 CIDDNVDMVK 100 FLVENGANIN 110 QPDNEGWIPL 120 HAAASCGYLD 130 IAEFLIGQGA 140 HVGAVNSEGD 150 TPLDIAEEEA 160 MEELLQNEVN 170 RQGVDIEAAR 180 KEEERIMLRD 190 ARQWLNSGHI 200 SDVRHAKSGG 210 TALHVAAAKG 220 YTEVLKLLIQ 230 AGYDVNIKDY 240 DGWTPLHAAA 250 HWGKEEACRI 260 LVDNLCDMET 270 VNKVGQTAFD 280 VADEDILGYL 290 EELQKKQNLL 300 HSEKRDKKSP 310 LIESTANMEN 320 NQPQKTFKNK 330 ETLIIEPEKN 340 ASRIESLEQE 350 KADEEEEGKK 360 DESSCSSEED 370 EEDDSESEAE 380 TDKTKPMASV 390 TNAHTASTQA 400 APAAVTTPTL 410 SSNQGTPTSP 420 VKKFPTSTTK 430 ISPKEEERKD 440 ESPASWRLGL 450 RKTGSYGALA 460 EITASKEAQK 470 EKDTAGVIRS 480 ASSPRLSSSL 490 DNKEKEKDNK 500 GTRLAYVAPT 510 IPRRLGSTSD 520 IEEKENRESS 530 NLRTSSSYTR 540 RKWEDDLKKN 550 SSINEGSTYH 560 RRSYLTPVRD 570 EESESQRKAR 580 SRQARQSRRS 590 TQGVTLTDLQ 600 EAEKTIGRSR 610 STRTREQENE 620 EKDKEEKEKQ 630 DKEKQEEKKE 640 SEVSREDEYK 650 QKYSRTYDET 660 YARYRPVSTS 670 SSSTPSSSSL 680 STLGSSLYAS 690 SQLNRPNSLV 700 GITSAYSRGL 710 TKDNEREGEK 720 KEEEKEGEDK 730 SQPKSIRERR 740 RPREKRRSTG 750 VSFWTQDSDE 760 NEQERQSDTE 770 DGSSKRDTQT 780 DSVSRYDSSS 790 TSSSDRYDSL 800 LGRSASYSYL 810 EERKPYGSRL 820 EKDDSTDFKK 830 LYEQILAENE 840 KLKAQLHDTN 850 MELTDLKLQL 860 EKATQRQERF 870 ADRSLLEMEK 880 RERRALERRI 890 SEMEEELKML 900 PDLKADNQRL 910 KDENGALIRV ISKLSK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0019208	phosphatase regulator activity
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0007165	signal transduction

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.