Search Results
Overview
| Uniprot ID | D4ADD7 |
|---|---|
| Protein Name | Glutaredoxin-related protein 5, mitochondrial |
| Gene Name | Glrx5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | DKVVVFLKGTPEQPQ |
| 209 | RSALIDEKDQDSK** |
Function
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1
Protein Sequence
10
MRLPGKAHRY
20
GVSDMIGGIE
30
PVLSNHETHP
40
RAYPMRTSSG
50
PAGHQGLCKP
60
SGGRRSGDQR
70
AGMSASLSRA
80
AAALLRWGRG
90
AGGGVLPRAG
100
VRAASSGGQA
110
EQLDALVKKD
120
KVVVFLKGTP
130
EQPQCGFSNA
140
VVQILRLHGV
150
RDYAAYNVLE
160
DPELRQGIKD
170
YSNWPTIPQV
180
YLNGEFVGGC
190
DILLQMHQNG
200
DLVEELKKLG
210
IRSALIDEKD
QDSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:1990229 | iron-sulfur cluster assembly complex |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0044571 | [2Fe-2S] cluster assembly |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.