Search Results
Overview
| Uniprot ID | D4ADT3 |
|---|---|
| Protein Name | Wings apart-like protein homolog |
| Gene Name | Wapl |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 162 | ANKSSCTKLITSDKV |
| 27 | FDEVFSNKRTTLSTK |
| 310 | YCRANKAKSSQGTSN |
| 415 | KADIATSKTTTRFRP |
| 594 | VTVRLSSKEPNQKDD |
| 599 | SSKEPNQKDDGVFKA |
| 605 | QKDDGVFKAPAPPLK |
Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair
Protein Sequence
10
MTSRFGKTYS
20
RKGGNGSSKF
30
DEVFSNKRTT
40
LSTKWGETTF
50
MAKLGQKRPN
60
FKPDIQEIPK
70
KPKVEEEDTG
80
DPFGFDSDDE
90
SLPVSSKSLA
100
QGKGSSYSES
110
SEAVQLEEVT
120
SVLEANSKCS
130
HAVGEDSFAS
140
DRCLLVEDSL
150
IGKEKNTNRI
160
PEDNANKSSC
170
TKLITSDKVE
180
NFSEEHEKNS
190
HHFHKNAEDS
200
TKKPNAETVA
210
ASECKADETK
220
TSDTWNSQSA
230
KRTESPSESC
240
PVKGSVRTGL
250
YEWDNDFEDI
260
RSEDCILSLD
270
NDSLLEMKDE
280
DLKNRIGGLE
290
NLNEAFEEDI
300
IQSVLRPSNC
310
RTYCRANKAK
320
SSQGTSNFDK
330
LMDGTSQTLA
340
KANSESSKDG
350
LNQAKKGSVS
360
CGTSFRGTVG
370
RTRDYTVLHP
380
SCLSVCNVTI
390
QDTMERSMDE
400
FTASTPADLG
410
EAGRLRKKAD
420
IATSKTTTRF
430
RPSNTKSKKD
440
VKLEFFGFED
450
HDETGGDEGG
460
SGSSNYKIKY
470
FGFDDLSESE
480
DDDDDDCQVE
490
RKKDKKRTKT
500
APSPSQQPPP
510
ESSDNSQDSQ
520
SSTNNAENLD
530
FTEDLPGVPE
540
SVKKPISKQG
550
DKSKENTRKI
560
FSGPKRSPTK
570
AVYNARHWNH
580
PDSEELPGPP
590
IVKPQSVTVR
600
LSSKEPNQKD
610
DGVFKAPAPP
620
LKVIKTVTIP
630
TQPYQEIVTA
640
LKCRKEDKEL
650
YTVVQHVKHF
660
NDVVEFGENQ
670
EFTDDIEYLL
680
SGLKSTQPLN
690
TRCLSVISLA
700
TKCAMPSFRM
710
HLRAHGMVAM
720
VFKTLDDSQH
730
HQNLSLCTAA
740
LMYILSRDRL
750
NMDLDRASLD
760
LMIRLLELEQ
770
DASSAKLLNE
780
KDMNKIKEKI
790
RRLCETVHNK
800
HLDLENITTG
810
HLAMETLLSL
820
TSKRAGDWFK
830
EELRLLGGLD
840
HIVDKVKECV
850
DHLSRDEDEE
860
KLVASLWGAE
870
RCLRVLESVT
880
VHNPENQSYL
890
IAYKDSQLII
900
SSAKALQHCE
910
DLIQQYNRAE
920
NSICIADSKP
930
LPYQNVTNHV
940
GKAVEDCMRA
950
IIGVLLNLTN
960
DNEWGSTKTG
970
EQEGLIGTAM
980
NCVLQVPKYL
990
PQEQRFDIRV
1000
LGLGLLINLV
1010
EYSARNRHCL
1020
VNMETSCSFD
1030
SSFSSGEGDH
1040
NLRLAGQVHA
1050
VQALVQLFLE
1060
RERAAQLAES
1070
KTDELIKDAP
1080
TTQHDKSGEW
1090
QETSGEIQWV
1100
STEKTDGAEE
1110
KQKKEDEDEE
1120
LDLNKALQHA
1130
GKHMEDCIVA
1140
SYTALLLGCL
1150
CQESPINVTT
1160
VREYLPEGDF
1170
SIMTEMLKKF
1180
LSFMNLTCAV
1190
GTTGQKSISR
VIEYLEHC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0042585 | germinal vesicle |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000795 | synaptonemal complex |
| Molecular Function | GO:0140083 | ATP-dependent protein-DNA unloader activity |
| Biological Process | GO:0008608 | attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0140588 | chromatin looping |
| Biological Process | GO:0007129 | homologous chromosome pairing at meiosis |
| Biological Process | GO:0051307 | meiotic chromosome separation |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0000070 | mitotic sister chromatid segregation |
| Biological Process | GO:0008156 | negative regulation of DNA replication |
| Biological Process | GO:0045875 | negative regulation of sister chromatid cohesion |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0071168 | protein localization to chromatin |
| Biological Process | GO:0060623 | regulation of chromosome condensation |
| Biological Process | GO:0051983 | regulation of chromosome segregation |
| Biological Process | GO:0051445 | regulation of meiotic cell cycle |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0007056 | spindle assembly involved in female meiosis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.