Search Results

Overview

Uniprot ID	D4AEC2
Protein Name	Calmodulin-regulated spectrin-associated protein 2
Gene Name	Camsap2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1457	HSHLWQTKRPVTPKK

Function

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:24908486). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity)

Protein Sequence

10 MGDAADPREV 20 RRTFIVPAIK 30 PFDHYDFSRA 40 KIACNLAWLV 50 AKAFGTETVP 60 EELREPFYTD 70 QYDQEHIKPP 80 VVNLLLSAEL 90 YCRAGSLILK 100 SDAAKPLLGH 110 DAVIQALAHK 120 GLYVTDQEKL 130 VTERDLHKKP 140 IQMSAHLAMI 150 DTLMMAYTVE 160 MVSIEKVIAC 170 AQQYSAFFQA 180 TDLPYDIEDA 190 VMYWINKVNE 200 HLKDIMEQEQ 210 KSKEHHTAEA 220 PGGQKSPSKW 230 FWKLVPARYR 240 KEQTLLKQLP 250 CIPLVENLLK 260 DGTDGCALAA 270 LIHFYCPAVV 280 RLEDICLKET 290 MSLADSLYNL 300 QLIQEFCQEY 310 LNHCCHFSLE 320 DMLYAASSIK 330 SNYLVFMAEL 340 FWWFEVVKPS 350 FVQPRVVRPQ 360 GAEPAKDMPS 370 VPVLNAAKRN 380 VLDSSSSSDF 390 TSRYTRPQTH 400 SSVSGGIRRS 410 SSMSYVDGFI 420 GTWPKEKRTS 430 VHGVSFDISF 440 DKEDNAQSST 450 PNRGIIRSVS 460 NEGLNNSRAS 470 KHIRKNLSFK 480 PVNGGEEESI 490 EEELHVDPHG 500 DLKSYMPLST 510 NELNSNENTH 520 HKLPNGALQN 530 RVLLDEFGNQ 540 IETPSIEEAL 550 QIIHDTEKPP 560 HTARPDQIAN 570 GFFLHGQDLS 580 LLNSNIKLSQ 590 SSPDNITDPK 600 GALSPITDTT 610 EVDTGIHVPS 620 EDIPETMDED 630 SSLRDYTVSL 640 DSDMDDASKF 650 LQDYDIRASN 660 PREALSPCPS 670 TISTKSQPGS 680 SASSSSGVKM 690 TSFAEQKFRK 700 LNHTDGKSSG 710 SSSQKTTPEG 720 SELNIPHMVS 730 WAQIPEESGV 740 AQGRDTTQLL 750 ASEMVHLRMR 760 LEEKRRAIEA 770 QKKKMEAAFT 780 KQRQKMGRTA 790 FLTVVKKKGD 800 GISPLREEAA 810 GAEDEKVYTD 820 RAKEKESQKM 830 DGQRSKSLAD 840 IKESMENPQG 850 KWLKSPSTPV 860 DPEKQWNLTS 870 PSEETLNEGE 880 LLEYTKSIEK 890 LNSSLHFLQQ 900 EMQRLSLQQE 910 MLMQMREQQS 920 WVISPPQPSP 930 QKQIRDFKPR 940 QAGLSSAAAP 950 FSADSPRPTH 960 PSPQSSTRKS 970 ASFSVKNQRT 980 PRPNELKITP 990 LNRTLTPPRS 1000 VDSLPRLRRF 1010 SPSQVPIQTR 1020 SFVCFGDDGE 1030 PQKEPKPKEE 1040 IKKEPSECKG 1050 TLESCDHNPG 1060 EKEVKPLEST 1070 VSEVLSQPIT 1080 ETVCVTPNED 1090 QLNQPTDPPP 1100 KPVFPPTAPK 1110 NVNLIEVSLS 1120 DLKPPEKADV 1130 SVEKFDGESD 1140 KEQFDDDQKV 1150 CCGFFFKDDQ 1160 KAENDMAVKR 1170 AALLEKRLRR 1180 EKETQLRKQQ 1190 LEAEMEHRKE 1200 ETRRKTEEER 1210 QKKEDERARR 1220 EFIRQEYMRR 1230 KQLKLMEDMD 1240 TVIKPRPQVA 1250 KQKKQRPKSI 1260 HRDHIESPKT 1270 PIKGPPVSSL 1280 SLASLNTGDT 1290 ESVHSGKRTP 1300 RSESVEGFLS 1310 PSRCGSRNGE 1320 KDWENASTTS 1330 SVASGTEYTG 1340 PKLYKEPSAK 1350 SNKHIIQNAL 1360 AHCCLAGKVN 1370 EGQKKKILEE 1380 MEKSDANNFL 1390 ILFRDSGCQF 1400 RSLYTYCPET 1410 EEINKLTGIG 1420 PKSITKKMIE 1430 GLYKYNSDRK 1440 QFSHIPAKTL 1450 SASVDAITIH 1460 SHLWQTKRPV 1470 TPKKLLPTKA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0036064	ciliary basal body
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:1990752	microtubule end
Cellular Component	GO:0036449	microtubule minus-end
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0051011	microtubule minus-end binding
Molecular Function	GO:0030507	spectrin binding
Biological Process	GO:0061564	axon development
Biological Process	GO:0031122	cytoplasmic microtubule organization
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0007026	negative regulation of microtubule depolymerization
Biological Process	GO:0050773	regulation of dendrite development
Biological Process	GO:1903358	regulation of Golgi organization
Biological Process	GO:0031113	regulation of microtubule polymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.