Search Results
Overview
| Uniprot ID | D4AEE9 |
|---|---|
| Protein Name | Transcription elongation factor 1 homolog |
| Gene Name | Elof1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | RKPPPKKKMTGTLET |
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II
Protein Sequence
10
MGRRKSKRKP
20
PPKKKMTGTL
30
ETQFTCPFCN
40
HEKSCDVKMD
50
RARNTGVISC
60
TVCLEEFQTP
70
ITYLSEPVDV
80
YSDWIDACEA
ANQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0008023 | transcription elongation factor complex |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0000993 | RNA polymerase II complex binding |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
| Biological Process | GO:0006283 | transcription-coupled nucleotide-excision repair |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.