Search Results
Overview
| Uniprot ID | D4AEP0 |
|---|---|
| Protein Name | Adenylosuccinate synthetase isozyme 2 |
| Gene Name | Adss2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | QRQEQAGKNLGTTKK |
Function
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Protein Sequence
10
MSISESSPAA
20
TSLPNGDCGR
30
PRARPGGNRV
40
TVVLGAQWGD
50
EGKGKVVDLL
60
AQDADIVCRC
70
QGGNNAGHTV
80
VVDSVEYDFH
90
LLPSGIINPN
100
VTAFIGNGVV
110
IHLPGLFEEA
120
EKNVQKGKGL
130
DGWEKRLIIS
140
DRAHIVFDFH
150
QAADGIQEQQ
160
RQEQAGKNLG
170
TTKKGIGPVY
180
SSKAARSGLR
190
MCDLVSDFDG
200
FSERFKVLAN
210
QYKSIYPTLE
220
IDIEGELQQL
230
KGYMERIKPM
240
VRDGVYFLYE
250
ALHGPPKKIL
260
VEGANAALLD
270
IDFGTYPFVT
280
SSNCTVGGVC
290
TGLGMPPQNV
300
GEVYGVVKAY
310
TTRVGIGAFP
320
TEQDNEIGEL
330
LQTRGREFGV
340
TTGRKRRCGW
350
LDLVLLKYAH
360
MINGFTALAL
370
TKLDILDMFT
380
EIKVGVAYKL
390
DGETIPHFPA
400
NQEVLNKVEV
410
QYKTLPGWNT
420
DISNARTFKE
430
LPVNAQNYVR
440
FIEDELQIPV
450
KWIGVGKSRE
SMIQLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004019 | adenylosuccinate synthase activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Biological Process | GO:0044208 | 'de novo' AMP biosynthetic process |
| Biological Process | GO:0006167 | AMP biosynthetic process |
| Biological Process | GO:0044209 | AMP salvage |
| Biological Process | GO:0006531 | aspartate metabolic process |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:0046040 | IMP metabolic process |
| Biological Process | GO:0006164 | purine nucleotide biosynthetic process |
| Biological Process | GO:0060359 | response to ammonium ion |
| Biological Process | GO:0014074 | response to purine-containing compound |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.