Search Results
Overview
| Uniprot ID | D4QEZ8 |
|---|---|
| Protein Name | Short-chain specific acyl-CoA dehydrogenase, mitochondrial |
| Gene Name | ACADS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | TPFTSGDKIGCFALS |
Function
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains
Protein Sequence
10
MAAALLARAS
20
GPARRALCPR
30
AWRQLHTIYQ
40
SVELPETHQM
50
LLQTCRDFAE
60
KELFPIAAQV
70
DKEHLFPAAQ
80
VKKMGGLGLL
90
AMDVPEELGG
100
AGLDYLAYAI
110
AMEEISRDCA
120
STGVIMSVNN
130
SLYLGPILKF
140
GSKEQKQAWV
150
TPFTSGDKIG
160
CFALSEPGNG
170
SDAGAASTTA
180
RAEGDSWVLN
190
GTKAWITNAW
200
EASAAVVFAS
210
TDRALQNKGI
220
SAFLVPMPTP
230
GLTLGKKEDK
240
LGIRGSSTAN
250
LIFEDCRIPK
260
DSILGEPGMG
270
FKIAMQTLDM
280
GRIGIASQAL
290
GIAQTALDCA
300
VNYAENRMAF
310
GAPLTKLQVI
320
QFKLADMALA
330
LESARLLTWR
340
AAMLKDNKKP
350
FIKEAAMAKL
360
AASEAATAIS
370
HQAIQILGGM
380
GYVTEMPAER
390
HYRDARITEI
400
YEGTSEIQRL
410
VIAGHLLRSY
RS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0016937 | short-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
Reference
PMID: N/A