Search Results
Overview
| Uniprot ID | D5KJI2 |
|---|---|
| Protein Name | High mobility group protein HMG-I/HMG-Y |
| Gene Name | HMGA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | SSQPLASKQEKDGTE |
| 31 | RGRGRPRKQPPVSPG |
| 46 | TALVGSQKEPSEVPT |
| 55 | PSEVPTPKRPRGRPK |
| 7 | *MSESSSKSSQPLAS |
| 74 | KGAAKTRKTTTAPGR |
Function
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions
Protein Sequence
10
MSESSSKSSQ
20
PLASKQEKDG
30
TEKRGRGRPR
40
KQPPVSPGTA
50
LVGSQKEPSE
60
VPTPKRPRGR
70
PKGSKNKGAA
80
KTRKTTTAPG
90
RKPRGRPKKL
100
EKEEEEGISQ
ESSEEEQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0010557 | positive regulation of macromolecule biosynthetic process |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.