Search Results
Overview
| Uniprot ID | D5KMS0 |
|---|---|
| Protein Name | Cytochrome P450 |
| Gene Name | CYP2D6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | RNLGLGKKSLEQWVT |
Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
Protein Sequence
10
MGLEALVPLA
20
VIVAIFLLLV
30
DLMHRRQRWA
40
ARYPPGPLPL
50
PGLGNLLHVD
60
FQNTPYCFDQ
70
LRRRFGDVFS
80
LQLAWTPVVV
90
LNGLAAVREA
100
LVTHGEDTAD
110
RPPVPITQIL
120
GFGPRSQGVF
130
LARYGPAWRE
140
QRRFSVSTLR
150
NLGLGKKSLE
160
QWVTKEAACL
170
CAAFANHSGR
180
PFRPNGLLDK
190
AVSNVIASLT
200
CGRRFEYDDP
210
RFLRLLDLAQ
220
EGLKEESGFL
230
REVLNAVPVL
240
LHIPALAGKV
250
LRFQKAFLTQ
260
LDELLTEHRM
270
TWDPAQPPRD
280
LTEAFLAEME
290
KAKGNPESSF
300
NDENLCIVVA
310
DLFSAGMVTT
320
STTLAWGLLL
330
MILHPDVQRR
340
VQQEIDDVIG
350
QVRRPEMGDQ
360
AHMPYTTAVI
370
HEVQRFGDIV
380
PLGVTHMTSR
390
DIEVQGFRIP
400
KGTTLITNLS
410
SVLKDEAVWE
420
KPFRFHPEHF
430
LDAQGHFVKP
440
EAFLPFSAGR
450
RACLGEPLAR
460
MELFLFFTSL
470
LQHFSFSVPT
480
GQPRPSHHGV
490
FAFLVTPSPY
ELCAVPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Reference
PMID: N/A