Search Results
Overview
| Uniprot ID | D9IAI1 |
|---|---|
| Protein Name | Phosphatidylethanolamine-binding protein 1 |
| Gene Name | HEL-S-34 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | YEQDRPLKCDEPILS |
| 157 | KVASFRKKYELRAPV |
Function
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation
Protein Sequence
10
MPVDLSKWSG
20
PLSLQEVDEQ
30
PQHPLHVTYA
40
GAAVDELGKV
50
LTPTQVKNRP
60
TSISWDGLDS
70
GKLYTLVLTD
80
PDAPSRKDPK
90
YREWHHFLVV
100
NMKGNDISSG
110
TVLSDYVGSG
120
PPKGTGLHRY
130
VWLVYEQDRP
140
LKCDEPILSN
150
RSGDHRGKFK
160
VASFRKKYEL
170
RAPVAGTCYQ
180
AEWDDYVPKL
YEQLSGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
Reference
PMID: N/A