Overview
| Uniprot ID | E7EI20 |
|---|
| Protein Name | Rho GDP-dissociation inhibitor 1 |
|---|
| Gene Name | ARHGDIA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 105 |
KKQSFVLKEGVEYRI |
| 127 |
REIVSGMKYIQHTYR |
| 141 |
RKGVKIDKTDYMVGS |
| 178 |
ARGSYSIKSRFTDDD |
| 43 |
QEIQELDKDDESLRK |
| 52 |
DESLRKYKEALLGRV |
| 99 |
GDLESFKKQSFVLKE |
Function
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1
Protein Sequence
10
MAEQEPTAEQ
20
LAQIAAENEE
30
DEHSVNYKPP
40
AQKSIQEIQE
50
LDKDDESLRK
60
YKEALLGRVA
70
VSADPNVPNV
80
VVTRLTLVCS
90
TAPGPLELDL
100
TGDLESFKKQ
110
SFVLKEGVEY
120
RIKISFRVNR
130
EIVSGMKYIQ
140
HTYRKGVKID
150
KTDYMVGSYG
160
PRAEEYEFLT
170
PMEEAPKGML
180
ARGSYSIKSR
190
FTDDDRTDHL
200
SWEWNLTIKK
EWKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0005094 |
Rho GDP-dissociation inhibitor activity |
| Biological Process |
GO:0035023 |
regulation of Rho protein signal transduction |
| Biological Process |
GO:0098693 |
regulation of synaptic vesicle cycle |
| Biological Process |
GO:0007266 |
Rho protein signal transduction |
| Biological Process |
GO:0071526 |
semaphorin-plexin signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.