Search Results

Overview

Uniprot IDE7EQS8
Protein NameMethylcytosine dioxygenase TET
Gene NameTET2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
774 QKLQIKNKEEILQTF

Function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development

Protein Sequence

10 MIQEEQIQLE 20 GSLVDGPEAS 30 LMEQDRTNHV 40 EGNRLSPFLI 50 PSPPICQTEP 60 LATKLQNGSP 70 LPERAHPEVN 80 GDTKWHSFKS 90 YYGIPCMKGS 100 QNSRVSPDFT 110 QESRGYSKCL 120 QNGGIKRTVS 130 EPSLSGLLQI 140 KKLKQDQKAN 150 GERRNFGVSQ 160 ERNPGESSQP 170 NVSDLSDKKE 180 SVSSVAQENA 190 VKDFTSFSTH 200 NCSGPENPEL 210 QILNEQEGKS 220 ANYHDKNIVL 230 LKNKAVLMPN 240 GATVSASSVE 250 HTHGELLEKT 260 LSQYYPDCVS 270 IAVQKTTSHI 280 NAINSQATNE 290 LSCEITHPSH 300 TSGQINSAQT 310 SNSELPPKPA 320 AVVSEACDAD 330 DADNASKLAA 340 MLNTCSFQKP 350 EQLQQQKSVF 360 EICPSPAENN 370 IQGTTKLASG 380 EEFCSGSSSN 390 LQAPGGSSER 400 YLKQNEMNGA 410 YFKQSSVFTK 420 DSFSATTTPP 430 PPSQLLLSPP 440 PPLPQVPQLP 450 SEGKSTLNGG 460 VLEEHHHYPN 470 QSNTTLLREV 480 KIEGKPEAPP 490 SQSPNPSTHV 500 CSPSPMLSER 510 PQNNCVNRND 520 IQTAGTMTVP 530 LCSEKTRPMS 540 EHLKHNPPIF 550 GSSGELQDNC 560 QQLMRNKEQE 570 ILKGRDKEQT 580 RDLVPPTQHY 590 LKPGWIELKA 600 PRFHQAESHL 610 KRNEASLPSI 620 LQYQPNLSNQ 630 MTSKQYTGNS 640 NMPGGLPRQA 650 YTQKTTQLEH 660 KSQMYQVEMN 670 QGQSQGTVDQ 680 HLQFQKPSHQ 690 VHFSKTDHLP 700 KAHVQSLCGT 710 RFHFQQRADS 720 QTEKLMSPVL 730 KQHLNQQASE 740 TEPFSNSHLL 750 QHKPHKQAAQ 760 TQPSQSSHLP 770 QNQQQQQKLQ 780 IKNKEEILQT 790 FPHPQSNNDQ 800 QREGSFFGQT 810 KVEECFHGEN 820 QYSKSSEFET 830 HNVQMGLEEV 840 QNINRRNSPY 850 SQTMKSSACK 860 IQVSCSNNTH 870 LVSENKEQTT 880 HPELFAGNKT 890 QNLHHMQYFP 900 NNVIPKQDLL 910 HRCFQEQEQK 920 SQQASVLQGY 930 KNRNQDMSGQ 940 QAAQLAQQRY 950 LIHNHANVFP 960 VPDQGGSHTQ 970 TPPQKDTQKH 980 AALRWHLLQK 990 QEQQQTQQPQ 1000 TESCHSQMHR 1010 PIKVEPGCKP 1020 HACMHTAPPE 1030 NKTWKKVTKQ 1040 ENPPASCDNV 1050 QQKSIIETME 1060 QHLKQFHAKS 1070 LFDHKALTLK 1080 SQKQVKVEMS 1090 GPVTVLTRQT 1100 TAAELDSHTP 1110 ALEQQTTSSE 1120 KTPTKRTAAS 1130 VLNNFIESPS 1140 KLLDTPIKNL 1150 LDTPVKTQYD 1160 FPSCRCVEQI 1170 IEKDEGPFYT 1180 HLGAGPNVAA 1190 IREIMEERFG 1200 QKGKAIRIER 1210 VIYTGKEGKS 1220 SQGCPIAKWV 1230 VRRSSSEEKL 1240 LCLVRERAGH 1250 TCEAAVIVIL 1260 ILVWEGIPLS 1270 LADKLYSELT 1280 ETLRKYGTLT 1290 NRRCALNEER 1300 TCACQGLDPE 1310 TCGASFSFGC 1320 SWSMYYNGCK 1330 FARSKIPRKF 1340 KLLGDDPKEE 1350 EKLESHLQNL 1360 STLMAPTYKK 1370 LAPDAYNNQI 1380 EYEHRAPECR 1390 LGLKEGRPFS 1400 GVTACLDFCA 1410 HAHRDLHNMQ 1420 NGSTLVCTLT 1430 REDNREFGGK 1440 PEDEQLHVLP 1450 LYKVSDVDEF 1460 GSVEAQEEKK 1470 RSGAIQVLSS 1480 FRRKVRMLAE 1490 PVKTCRQRKL 1500 EAKKAAAEKL 1510 SSLENSSNKN 1520 EKEKSAPSRT 1530 KQTENASQAK 1540 QLAELLRLSG 1550 PVMQQSQQPQ 1560 PLQKQPPQPQ 1570 QQQRPQQQQP 1580 HHPQTESVNS 1590 YSASGSTNPY 1600 MRRPNPVSPY 1610 PNSSHTSDIY 1620 GSTSPMNFYS 1630 TSSQAAGSYL 1640 NSSNPMNPYP 1650 GLLNQNTQYP 1660 SYQCNGNLSV 1670 DNCSPYLGSY 1680 SPQSQPMDLY 1690 RYPSQDPLSK 1700 LSLPPIHTLY 1710 QPRFGNSQSF 1720 TSKYLGYGNQ 1730 NMQGDGFSSC 1740 TIRPNVHHVG 1750 KLPPYPTHEM 1760 DGHFMGATSR 1770 LPPNLSNPNM 1780 DYKNGEHHSP 1790 SHIIHNYSAA 1800 PGMFNSSLHA 1810 LHLQNKENDM 1820 LSHTANGLSK 1830 MLPALNHDRT 1840 ACVQGGLHKL 1850 SDANGQEKQP 1860 LALVQGVASG 1870 AEDNDEVWSD 1880 SEQSFLDPDI 1890 GGVAVAPTHG 1900 SILIECAKRE 1910 LHATTPLKNP 1920 NRNHPTRISL 1930 VFYQHKSMNE 1940 PKHGLALWEA 1950 KMAEKAREKE 1960 EECEKYGPDY 1970 VPQKSHGKKV 1980 KREPAEPHET 1990 SEPTYLRFIK 2000 SLAERTMSVT 2010 TDSTVTTSPY 2020 AFTRVTGPYN RYI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0070579 DNA 5-methylcytosine dioxygenase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway
Biological Process GO:0040029 epigenetic regulation of gene expression
Biological Process GO:0010557 positive regulation of macromolecule biosynthetic process

Reference

PMID: N/A