Search Results

Overview

Uniprot IDE9PAV3
Protein NameNascent polypeptide-associated complex subunit alpha, muscle-specific form
Gene NameNACA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1945 KARKAMSKLGLRQVT
1963 RVTIRKSKNILFVIT
2005 AQLAAAEKFKVQGEA
2007 LAAAEKFKVQGEAVS

Function

Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity)

Protein Sequence

10 MPGEATETVP 20 ATEQELPQPQ 30 AETAVLPMSS 40 ALSVTAALGQ 50 PGPTLPPPCS 60 PAPQQCPLSA 70 ANQASPFPSP 80 STIASTPLEV 90 PFPQSSSGTA 100 LPLGTAPEAP 110 TFLPNLIGPP 120 ISPAALALAS 130 PMIAPTLKGT 140 PSSSAPLALV 150 ALAPHSVQKS 160 SAFPPNLLTS 170 PPSVAVAESG 180 SVITLSAPIA 190 PSEPKTNLNK 200 VPSEVVPNPK 210 GTPSPPCIVS 220 TVPYHCVTPM 230 ASIQSGVASL 240 PQTTPTTTLA 250 IASPQVKDTT 260 ISSVLISPQN 270 PGSLSLKGPV 280 SPPAALSLST 290 QSLPVVTSSQ 300 KTAGPNTPPD 310 FPISLGSHLA 320 PLHQSSFGSV 330 QLLGQTGPSA 340 LSDPTVKTIS 350 VDHSSTGASY 360 PSQRSVIPPL 370 PSRNEVVPAT 380 VAAFPVVAPS 390 VDKGPSTISS 400 ITCSPSGSLN 410 VATSFSLSPT 420 TSLILKSSPN 430 ATYHYPLVAQ 440 MPVSSVGTTP 450 LVVTNPCTIA 460 AAPTTTFEVA 470 TCVSPPMSSG 480 PISNIEPTSP 490 AALVMAPVAP 500 KEPSTQVATT 510 LRIPVSPPLP 520 DPEDLKNLPS 530 SVLVKFPTQK 540 DLQTVPASLE 550 GAPFSPAQAG 560 LTTKKDPTVL 570 PLVQAAPKNS 580 PSFQSTSSSP 590 EIPLSPEATL 600 AKKSLGEPLP 610 IGKPASSMTS 620 PLGVNSSASV 630 IKTDSYAGPD 640 SAGPLLKSSL 650 ITPTVAAFPL 660 ESADPAGVAP 670 TTAKGTSTYT 680 TTASPFLEGT 690 VSLAPKNHPV 700 KEGTLTTLPL 710 VPTASENCPV 720 APSPQNTCAP 730 LATLVLAPEI 740 PKSVPSPSLP 750 PAGTPPGTKK 760 VDGISHTSAL 770 APVASSPKEC 780 PTEDSGASAT 790 ASSKGTLTYL 800 ADSPSPLGVS 810 VSPQTKRPPT 820 KKGSAGPDTP 830 IGNLSSPVSP 840 VEASFLPENS 850 LSFQGSKDSP 860 ATTHSPTPPS 870 PKGAPTPSAV 880 TPLSPKGVTL 890 PPKETPTPSV 900 VNLPFPKEGP 910 ATPAPKQAPA 920 LSMTSSSPKK 930 ARATPAPKGI 940 PASPSPKGAP 950 TPPAATPPSP 960 KGGPATPSPK 970 WAPTPPAATP 980 PSPKGGPATP 990 SPKGAPTPPA 1000 ATPPSPKGGP 1010 ATPSPKGAPT 1020 PPAVTPPSPK 1030 GSPAATPFPK 1040 GASTPPAATP 1050 PSPKGSPAAT 1060 PLPKGAPTTP 1070 AATLPSPKGG 1080 PATPSLKGAP 1090 TPPAATPPSP 1100 KGGPATPSPK 1110 GAPMPPAATP 1120 PSPKGGLATP 1130 PHKGAPTTPA 1140 ATPPSPKGGL 1150 ATPPPKGAPT 1160 TPAATPPSPK 1170 GGLATPPPKG 1180 APTTPAATPP 1190 SPKGGLATPS 1200 PKGAPTTPAA 1210 TPPSPKGGLA 1220 TPSPKGAPTT 1230 PAATPPSPKG 1240 GLATPSPKGA 1250 PTTPAATPPS 1260 PKGGPATPPP 1270 KGAPTPPAAT 1280 PPSLKGGLAT 1290 PPHKGAPNPA 1300 VVTPPSPKGG 1310 PATSPPKGAP 1320 TPPAATPPSP 1330 KGSPGTPPPK 1340 GAPTPPAVTP 1350 PSPKGTPTLP 1360 ATTPSSKGGP 1370 TTPSSKEGPT 1380 PPAATPSHKG 1390 GPAMTPPSPK 1400 RGPAIPSPKG 1410 DPTSPAVIPL 1420 SPKKAPATPV 1430 TREGAATPSK 1440 GDLTPPAVTP 1450 VSLKKAPATS 1460 APKGGPATPS 1470 SKGDPTLPAV 1480 TPPSPKEPPA 1490 PKQVATSSSP 1500 KKAPATPAPM 1510 GAPTLPAVIP 1520 SSPKEVPATP 1530 SSRRDPIAPT 1540 ATLLSKKTPA 1550 TLAPKEALIP 1560 PAMTVPSPKK 1570 TPAIPTPKEA 1580 PATPSSKEAS 1590 SPPAVTPSTY 1600 KGAPSPKELL 1610 IPPAVTSPSP 1620 KEAPTPPAVT 1630 PPSPEKGPAT 1640 PAPKGTPTSP 1650 PVTPSSLKDS 1660 PTSPASVTCK 1670 MGATVPQASK 1680 GLPAKKGPTA 1690 LKEVLVAPAP 1700 ESTPIITAPT 1710 RKGPQTKKSS 1720 ATSPPICPDP 1730 SAKNGSKGPL 1740 STVAPAPLLP 1750 VQKDSSKTAK 1760 GKDASHSPKG 1770 PLAPPESKAS 1780 TPLTAAAFEK 1790 VLPKPESASV 1800 SAAPSPPVSL 1810 PLAPSPVPTL 1820 PPKQQFLPSS 1830 PGLVLESPSK 1840 PLAPADEDEL 1850 LPLIPPEPIS 1860 GGVPFQSVLV 1870 NMPTPKSAGI 1880 PVPTPSAKQP 1890 VTKNNKGSGT 1900 ESDSDESVPE 1910 LEEQDSTQAT 1920 TQQAQLAAAA 1930 EIDEEPVSKA 1940 KQSRSEKKAR 1950 KAMSKLGLRQ 1960 VTGVTRVTIR 1970 KSKNILFVIT 1980 KPDVYKSPAS 1990 DTYIVFGEAK 2000 IEDLSQQAQL 2010 AAAEKFKVQG 2020 EAVSNIQENT 2030 QTPTVQEESE 2040 EEEVDETGVE 2050 VKDIELVMSQ 2060 ANVSRAKAVR 2070 ALKNNSNDIV NAIMELTM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005854 nascent polypeptide-associated complex
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006612 protein targeting to membrane

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.