Search Results

Overview

Uniprot ID	E9PRG8
Protein Name	28S rRNA/ribosome and sororin micro-cofactor
Gene Name	RSMC
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
103	RTSEPQLKRQKKTKA
109	LKRQKKTKAPQDVEM

Function

Promotes sister chromatid cohesion by enhancing recruitment of CDCA5/sororin to chromatin during S phase and stimulating the anti-WAPL activity of CDCA5 (PubMed:41261216). Associates with the pre-60S ribosome and may be involved in pre-60S ribosome assembly (PubMed:37491604)

Protein Sequence

10 MGAPGGKINR 20 PRTELKKKLF 30 KRRRVLNRER 40 RLRHRVVGAV 50 IDQGLITRHH 60 LKKRASSARA 70 NITLSGKKRR 80 KLLQQIRLAQ 90 KEKTAMEVEA 100 PSKPARTSEP 110 QLKRQKKTKA 120 PQDVEMKDLE DES

Gene Ontology

No Gene Ontology data available.

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.